Hepatitis B virus

Establishment of reference sequences of hepatitis B virus genotype C subgenotypes

H. L. Zhu, Wang, C. T., Xia, J. B., Li, X., and Zhang, Z. H., Establishment of reference sequences of hepatitis B virus genotype C subgenotypes, vol. 14, pp. 16521-16534, 2015.

Hepatitis B virus genotype C (HBV/C) has the largest number of subgenotypes (C1-C16) that vary with geography and isolates. HBV/C prevails in Southeast Asia (C1, C5-C16), East Asia (C2), Oceania (C3), and Australia (C4). Suitable reference strains for different subgenotypes could greatly facilitate research into HBV/C, but unfortunately they are scarce. We retrieved 974 HBV/C full-length sequences from the GenBank database and subgenotyped them by phylogenetic analysis.

-173G/C polymorphism in the promoter of MIF is associated with hepatitis B virus infection in a Chinese Han population

Z. S. Wang, Yin, C. C., Han, S., Jiang, F. L., Guo, W. G., Wu, L. Q., and Liu, S. H., -173G/C polymorphism in the promoter of MIF is associated with hepatitis B virus infection in a Chinese Han population, vol. 14, pp. 8532-8538, 2015.

In addition to the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. The macrophage migration inhibitory factor (MIF) -173G/C polymorphism (rs755622), located in the promoter region of MIF, may play integral roles in diverse processes, including the immune response. Thus, the MIF -173G/C polymorphism may influence the immune response to HBV during natural infection.

Synonymous codon selection in the hepatitis B virus translation initiation region

M. - R. Ma, Hui, L., Wang, M. - L., Tang, Y., Chang, Y. - W., Jia, Q. - H., Yang, X. - P., Wang, X. - H., and Ha, X. - Q., Synonymous codon selection in the hepatitis B virus translation initiation region, vol. 14, pp. 8955-8963, 2015.

Hepatitis B virus (HBV) infection is a major health problem worldwide. This virus and its hosts are often fated to continual co-evolutionary interactions. Codon usage analysis has significance for studies of co-evolution between viruses, their hosts, and mRNA translation.

Antiviral effect of hepatitis B virus S/C gene loci antisense locked nucleic acid on transgenic mice in vivo

Y. B. Deng, Qin, H. J., Luo, Y. H., Liang, Z. R., and Zou, J. J., Antiviral effect of hepatitis B virus S/C gene loci antisense locked nucleic acid on transgenic mice in vivo, vol. 14, pp. 10087-10095, 2015.

We investigated the effects of hepatitis B virus (HBV) S/C double gene loci antisense locked nucleic acid on replication and expression of HBV in hepatitis transgenic mice. HBV mice (N = 30) were randomly divided into five groups of six mice: 5% glucose solution control, empty liposome control, single-target S, single-target C, and dual-target SC groups. An antisense locked nucleic acid fragment was injected into the mice.

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