Heat shock protein messenger RNA

Temporal variations of Hsp60 and HSF-1 in primary rat myocardial cells in vitro under heat stress

R. Buriro, Lv, Y. J., Ali, I., Tang, S., Liu, Z. J., Zhang, M., Adem, A., Hartung, J., and Bao, E. D., Temporal variations of Hsp60 and HSF-1 in primary rat myocardial cells in vitro under heat stress, vol. 12, pp. 3003-3016, 2013.

The mechanisms involved in sudden animal death due to acute heart failure during heat stress are not well understood. We examined the relationship between heat stress-induced variations of protective Hsp60 and expression of its regulatory factor, HSF-1, in heat-stressed primary myocardial cells of neonatal rats in vitro through cardiac enzyme detection, immunoblotting, immunocytochemistry, and qPCR. Increases in cardiac damage-related enzyme levels demonstrated injury to myocardial cells after heat exposure at 42°C.

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