Heat shock protein 70

Detection of serum anti-melanocyte antibodies and identification of related antigens in patients with vitiligo

M. C. Zhu, Liu, C. G., Wang, D. X., and Zhan, Z., Detection of serum anti-melanocyte antibodies and identification of related antigens in patients with vitiligo, vol. 14, pp. 16060-16073, 2015.

We detected autoantibodies against melanocytes in serum samples obtained from 50 patients, including 4 with HBV, with vitiligo and identified the associated membrane antigens. Heat shock protein 70 (HSP70) and anti-tyrosinase-related protein 1 (TRP-1) antibody levels were analyzed. The associated antigens in normal human melanocyte were identified by immunofluorescence. Autoantibodies against melanocyte membrane and cytoplasmic proteins were detected by western blot. Membrane antigens with higher frequencies were identified by protein mass spectrometry.

Heat shock protein 70 polymorphisms in Chinese patients with Graves’ disease

Y. P. Wang, Tang, Z., Peng, B. K., Zhen, Q., Zhou, S. L., and Jin, X. F., Heat shock protein 70 polymorphisms in Chinese patients with Graves’ disease, vol. 14, pp. 18376-18383, 2015.

Graves’ disease (GD) is a common autoimmune disease mainly affecting the thyroid. However, the correlation between the development of GD and HSP70 alleles has not been reported in the Chinese population. Therefore, the aim of this study was to investigate the association between HSP70 polymorphisms and GD in the Chinese population.

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