Heat shock protein 60

Characterization of the Toxoplasma gondii hsp60 gene sequences from different hosts and geographical locations

J. Lu, Zhou, D. H., Chen, J., Zhang, N. Z., Wang, R. A., Weng, Y. B., and Zhu, X. Q., “Characterization of the Toxoplasma gondii hsp60 gene sequences from different hosts and geographical locations”, vol. 13, pp. 6906-6911, 2014.

The intracellular protozoan Toxoplasma gondii is one of the most successful parasites, with the ability to invade all warm-blooded animals, including humans. T. gondii heat shock protein 60 (TgHSP60) plays an important role in intracellular survival and in the differentiation of the parasite, and is also recognized as being associated with its virulence. In the present study, we examined sequence variation in the hsp60 coding region among five T.

Temporal variations of Hsp60 and HSF-1 in primary rat myocardial cells in vitro under heat stress

R. Buriro, Lv, Y. J., Ali, I., Tang, S., Liu, Z. J., Zhang, M., Adem, A., Hartung, J., and Bao, E. D., “Temporal variations of Hsp60 and HSF-1 in primary rat myocardial cells in vitro under heat stress”, vol. 12, pp. 3003-3016, 2013.

The mechanisms involved in sudden animal death due to acute heart failure during heat stress are not well understood. We examined the relationship between heat stress-induced variations of protective Hsp60 and expression of its regulatory factor, HSF-1, in heat-stressed primary myocardial cells of neonatal rats in vitro through cardiac enzyme detection, immunoblotting, immunocytochemistry, and qPCR. Increases in cardiac damage-related enzyme levels demonstrated injury to myocardial cells after heat exposure at 42°C.

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