Heart failure

 Association between β1 adrenergic receptor gene Arg389Gly polymorphism and risk of heart failure: a meta-analysis

S. T. Ma, Zhao, W., Liu, B., Jia, R. Y., Zhao, C. J., and Cui, L. Q.,  Association between β1 adrenergic receptor gene Arg389Gly polymorphism and risk of heart failure: a meta-analysis, vol. 14, pp. 5922-5929, 2015.

Numerous studies have evaluated the association between Arg389Gly polymorphism in the β1 adrenergic receptor gene and heart failure risk. However, the specific association is still controversial. We performed a meta-analysis of all case-control studies that evaluated the association between Arg389Gly polymorphism and heart failure in humans. Studies were identified in the PubMed, Embase, and China National Knowledge Infrastructure databases. Two reviewers independently assessed the studies.

Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure

X. S. Gu, Wang, Z. B., Ye, Z., Lei, J. P., Li, L., Su, D. F., and Zheng, X., Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure, vol. 13, pp. 323-335, 2014.

Reduced AMP-activated protein kinase (AMPK) expression has been shown to play a significant role in the cardiac dysfunction in heart failure. This study was designed to examine the effect of resveratrol, a potent activator of silent information regulator (SIRT1), on cardiac function and AMPK expression in heart failure. Adult male rat left anterior descending arteries were ligated, and they were fed with either a regular diet or a diet enriched with resveratrol.

Torasemide reduces dilated cardiomyopathy, complication of arrhythmia, and progression to heart failure

L. N. Han, Guo, S. L., Lin, X. M., Shi, X. M., Zang, C. B., Yang, L. M., and Ding, G. L., Torasemide reduces dilated cardiomyopathy, complication of arrhythmia, and progression to heart failure, vol. 13, pp. 7262-7274, 2014.

The aim of this study was to analyze the incidence and types of arrhythmia and their relationship with the severity and prognosis of chronic heart failure (CHF) in patients with dilated cardiomyopathy (DCM), and to investigate the therapeutic effect of torasemide versus furosemide on CHF and incidence of arrhythmia. DCM patients with NYHA cardiac function II-IV were continuously monitored using a 24-h dynamic electrocardiogram (Holter), and arrhythmia incidence was analyzed by computer automatic analysis combined with manual assessment.

Transcriptome network analysis of potential candidate genes for heart failure

J. Chen, Wang, H. Y., and Zeng, C. Y., Transcriptome network analysis of potential candidate genes for heart failure, vol. 12, pp. 4687-4697, 2013.

The purpose of this study was to examine the hypothesis that a transcriptome network can be developed through a set of transcription factors regulated by the expression of various genes induced by dilated cardiomyopathy can be identified and modulated to respond to heart failure. We searched for significant pathways related to dilated cardiomyopathy using the GSE4172 microarray data to identify potential genes related to heart failure.

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