Head and neck squamous cell carcinoma

Characterization of gene methylation in human papillomavirus associated-head and neck squamous cell carcinoma

H. Z. Zhang, Shan, C. G., Huang, A. P., Wang, J. M., Zhang, H. Z., Shan, C. G., Huang, A. P., and Wang, J. M., Characterization of gene methylation in human papillomavirus associated-head and neck squamous cell carcinoma, vol. 15, p. -, 2016.

Head and neck squamous cell carcinoma (HNSCC) has become one of the most common forms of cancer worldwide. Hypermethylation-induced silencing of tumor-associated gene has been proposed as an important cofactor in cancer pathology. This paper aimed to characterize the gene methylation patterns in human papillomavirus (HPV) associated-HNSCC. TIMP3 and APC methylation status in neoplastic (N = 92) and non-neoplastic tissues (N = 92) of HNSCC as well as their association with HPV infection were investigated via methylation-specific PCR assays.

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