Head and neck cancer

Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism

E. Stur, Agostini, L. P., Garcia, F. M., Peterle, G. T., Maia, L. L., Mendes, S. O., Anders, Q. S., Reis, R. S., Santos, J. A., Ventorim, D. P., Carvalho, M. B., Tajara, E. H., Santos, M., Paula, F., Silva-Conforti, A. M. A., and Louro, I. D., Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism, vol. 14, pp. 12446-12454, 2015.

The aims of this study were to analyze the polymorphisms XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPC Lys939Gln, ERCC1 Asn118Asn, and RAD51 -98G>C and to verify their influence on radiotherapy response and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). Peripheral blood DNA was extracted from 311 patients and analyzed by PCR-RFLP.

MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell carcinoma

Q. S. Anders, Stur, E., Agostini, L. P., Garcia, F. M., Reis, R. S., Santos, J. A., Mendes, S. O., Maia, L. L., Peterle, G. T., Stange, V., Carvalho, M. B., Tajara, E. H., Santos, M., Silva-Conforti, A. M. A., and Louro, I. D., MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell carcinoma, vol. 14, pp. 13105-13109, 2015.

The C677T and A1298C polymorphisms in methylene­tetrahydrofolate reductase (MTHFR), which regulates the release of active folate in the body, may have reduced activity. Given that folate participates in important intracellular pathways, such as nucleotide synthesis and biomolecule methylation, it seems plausible that patients with head and neck squamous cell carcinoma (HNSCC) may respond differently to radiotherapy treatments, based on genetic polymor­phisms. Therefore, this study sought to understand the role of these polymorphisms in HNSCC patient radiotherapy response.

Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer

P. R. S. Rodrigues, Maia, L. L., Santos, M., Peterle, G. T., Alves, L. U., Takamori, J. T., Souza, R. P., Barbosa, W. M., Mercante, A. M. C., Nunes, F. D., Carvalho, M. B., Tajara, E. H., Louro, I. D., and Silva-Conforti, A. M. A., Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer, vol. 14, pp. 14979-14988, 2015.

The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been reported to alter receptor function and expression, both of which have been related with prognostics in several tumor types.

Identification of microRNAs as diagnostic biomarkers in screening of head and neck cancer: a meta-analysis

M. Zhang, Zhao, L. J., Liang, W. Q., and Mao, Z. P., Identification of microRNAs as diagnostic biomarkers in screening of head and neck cancer: a meta-analysis, vol. 14, pp. 16562-16576, 2015.

Head and neck cancer (HNC) is one of the most prevalent cancers; it is often diagnosed at its advanced stage and has a low 5-year survival rate. Evidence suggests that noninvasive biomarker microRNAs (miRNAs) are valuable for early diagnosis of HNC. This meta-analysis assessed the diagnostic value of miRNAs in HNC detection. A systematic literature search for relevant studies up to August 4, 2014 was conducted in databases and other sources. Statistical analysis was conducted using STATA 12.0.

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