Head and neck cancer

Analysis of TP53 gene expression and p53 level of human hypopharyngeal FaDu (HTB-43) head and neck cancer cell line after microRNA-181a inhibition

Y. K. Cheah, Cheng, R. W., Yeap, S. K., Khoo, C. H., and See, H. S., Analysis of TP53 gene expression and p53 level of human hypopharyngeal FaDu (HTB-43) head and neck cancer cell line after microRNA-181a inhibition, vol. 13, pp. 1679-1683, 2014.

The identification of new biomarkers for early detection of highly recurrent head and neck cancer is urgently needed. MicroRNAs (miRNAs) are small and non-coding RNAs that regulate cancer-related gene expression, such as tumor protein 53 (TP53) gene expression. This study was carried out to analyze TP53 gene expression using real-time PCR and to determine changes in intracellular p53 level by flow cytometry after downregulation of miRNA-181a miRNA inhibitor in the FaDu cell line.

Association between XPD Lys751Gln polymorphism and risk of head and neck cancer: a meta-analysis

H. Yuan, Niu, Y. M., Wang, R. X., Li, H. Z., and Chen, N., Association between XPD Lys751Gln polymorphism and risk of head and neck cancer: a meta-analysis, vol. 10, pp. 3356-3364, 2011.

Several studies have investigated the association between Lys751Gln polymorphism in the xeroderma pigmentosum group D (XPD) gene and risk of head and neck cancer; however, the published results are conflicting. We conducted a meta-analysis that comprised 15 published case-control studies examining the association of head and neck cancer risk with XPD Lys751Gln polymorphism in different populations, based on the data identified in Medline up to November 2010. Odds ratios (ORs) with 95% confidence intervals (CI) were used to assess the strength of the association.

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