HBV mutation

Identification of a mutation in Hepatitis B virus surface antigen capable of evading ELISA screening

Y. Cui, Zhang, T., Yan, Y., Liu, K., Cui, Y., Zhang, T., Yan, Y., and Liu, K., Identification of a mutation in Hepatitis B virus surface antigen capable of evading ELISA screening, vol. 15, p. -, 2016.

Hepatitis B virus (HBV) infection can cause HBV-related cirrhosis, liver failure, and hepatocellular carcinoma. At present, a hepatitis B surface antigen (HBsAg) blood test is the primary clinical and diagnostic marker for the identification of a chronic HBV infection. In the current study, we isolated a novel HBV mutant from a chronic HBV patient, capable of causing a false negative test result for most (7 of 8) commercial HBsAg ELISA kits.

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