Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women
“Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women”, vol. 15, p. -, 2016.
, Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) in five hormone-related genes: estrogen receptor-α (ESR1), aromatase (CYP19), catechol-O-methyl transferase (COMT), sex hormone-binding globulin (SHBG), and glutathione S-transferase (GSTP1).