Haplogroup

Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China

Y. Fang, Yang, H. Y., Shi, Y. H., Cui, J. H., Li, L. Y., Xu, Y. C., and Shao, J. L., Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China, vol. 14, pp. 5031-5043, 2015.

Mitochondrial DNA mutations play crucial roles in the pathogenesis and progression of human malignancies. Therefore, to determine whether maternal background or mitochondrial DNA somatic mutations were essential cofactors in the lung cancer of Chinese patients as well, the complete mitochondrial DNA displacement loop of the primary cancerous, matched para-cancerous normal and distant normal tissues for 79 Chinese patients with lung cancer were analyzed in this study.

Mitochondrial haplogroup D4 confers resistance and haplogroup B is a genetic risk factor for high-altitude pulmonary edema among Han Chinese

Y. J. Luo, Gao, W. X., Li, S. Z., Huang, X. W., Chen, Y., Liu, F. Y., Huang, Q. Y., and Gao, Y. Q., Mitochondrial haplogroup D4 confers resistance and haplogroup B is a genetic risk factor for high-altitude pulmonary edema among Han Chinese, vol. 11, pp. 3658-3667, 2012.

High-altitude pulmonary edema (HAPE) is a life-threatening condition caused by acute exposure to high altitude. Accumulating evidence suggests that genetic factors play an important role in the etiology of HAPE. However, conclusions from association studies have been hindered by limited sample size due to the rareness of this disease. It is known that mitochondria are critical for hypoxic adaptation, and mitochondrial malfunction can be an important factor in HAPE development.

Subscribe to Haplogroup