Han Chinese population

Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population

C. M. Wang, Ye, H. D., Li, Y. R., Hong, Q. X., Tang, L. L., Zhou, A. N., Xu, M. Q., and Duan, S. W., Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population, vol. 14, pp. 12254-12261, 2015.

Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene polymorphisms were associated with CHD in Han Chinese. Our case-control study was involved with 1509 unrelated individuals, including 777 CHD cases and 732 controls.

Lack of association between rare mutations of the SIAE gene and rheumatoid arthritis in a Han Chinese population

D. D. Zhang, He, F., Liu, H. T., Hao, F., and Zhu, J., Lack of association between rare mutations of the SIAE gene and rheumatoid arthritis in a Han Chinese population, vol. 14, pp. 14162-14168, 2015.

The function of rare genotypes encoding defective variants of sialic acid acetylesterase (SIAE) in some autoimmune diseases, including rheumatoid arthritis (RA), is ambiguous. We determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population.DNA was prepared from the venous leukocytes of 444 RA patients and 647 normal controls. The coding regions and adjacent intron sequences of SIAE were amplified by polymerase chain reaction. The products were then subjected to sequencing analysis.

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