GSTM1 polymorphism

Association of the GSTM1 null polymorphism with breast cancer in a Mexican population

O. Soto-Quintana, Zúñiga-González, G. M., Ramírez-Patiño, R., Ramos-Silva, A., Figuera, L. E., Carrillo-Moreno, D. I., Gutiérrez-Hurtado, I. A., Puebla-Pérez, A. M., Sánchez-Llamas, B., and Gallegos-Arreola, M. P., Association of the GSTM1 null polymorphism with breast cancer in a Mexican population, vol. 14, pp. 13066-13075, 2015.

The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion in the mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotypes of 276 healthy Mexican women with those of 558 Mexican women with breast cancer (BC).

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