Gold nanoparticles

Transient increase in IL-1β, IL-6 and TNF-α gene expression in rat liver exposed to gold nanoparticles

H. A. Khan, Abdelhalim, M. A. K., Alhomida, A. S., and Ayed, M. S. Al, Transient increase in IL-1β, IL-6 and TNF-α gene expression in rat liver exposed to gold nanoparticles, vol. 12. pp. 5851-5857, 2013.

Most studies have used in vitro systems to test inflammatory responses of nanoparticles; these may not reflect the real biological response of body organs. In fact, certain nanoparticles have provoked opposite effects under in vitro and in vivo conditions. Current understanding of the biocompatibility of gold nanoparticles is controversial. We studied the acute (1 day) and sub-chronic (5 days) effects of gold nanoparticles (10 and 50 nm in diameter) on expression of interleukin-1 beta (IL-1β), IL-6 and tumor necrosis factor alpha (TNF-α) in rat liver.

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