Gluthatione S-transferase

Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro

P. Coutinho, Sandim, V., Oliveira, J. A., Alves, G., and Hatagima, A., Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro, vol. 9, pp. 539-544, 2010.

The glutathione S-transferases (GSTs), a family of phase II isozymes, detoxify several carcinogens. Genetic variations in GSTs have been associated with increased risk for cancer due to a heritable deficiency in detoxification pathways for environmental carcinogens. Conflicting findings have been reported about the association between constitutive GST polymorphisms and gliomas in different populations. The present case-control study examined 78 patients with primary glioma and 347 controls from Rio de Janeiro.

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