Glutathione S-transferases

Predictive potential role of glutathione S-transferases polymorphisms in response to chemotherapy and breast cancer prognosis

P. Yuan, Yuan, L., Xu, B. L., Wang, C. Z., Yang, H. Z., and Li, Y., Predictive potential role of glutathione S-transferases polymorphisms in response to chemotherapy and breast cancer prognosis, vol. 14, pp. 16675-16681, 2015.

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism.

Predictive potential role of glutathione S-transferase polymorphisms in the prognosis of breast cancer

X. Wang and Huang, Z. H., Predictive potential role of glutathione S-transferase polymorphisms in the prognosis of breast cancer, vol. 14, pp. 10236-10241, 2015.

The current study aimed at evaluating the associa­tion between GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms and clinical response to chemotherapy and treatment outcome of breast cancers patients. Genotyping of GSTP1 rs1695, GSTT1 deletion, and GSTM1 deletion was performed by Polymerase Chain Reaction Restriction Fragment Length Polymor­phism (PCR-RFLP) assay.

Glutathione S-transferase polymorphisms influence chemotherapy response and treatment outcome in breast cancer

J. Wang, Wang, T., Yin, G. - Y., Yang, L., Wang, Z. - G., and Bu, X. - B., Glutathione S-transferase polymorphisms influence chemotherapy response and treatment outcome in breast cancer, vol. 14, pp. 11126-11132, 2015.

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymor­phisms in the clinical response to chemotherapy and treatment outcome of patients with breast cancer. A total of 262 subjects were randomly selected from among patients with a histologically confirmed breast cancer. The genotypes of GSTM1, GSTT1, and GSTP1 IIe105Val poly­morphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis.

Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico

G. Jaramillo-Rangel, Ortega-Martínez, M., Cerda-Flores, R. M., and Barrera-Saldaña, H. A., Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico, vol. 14. pp. 6465-6471, 2015.

Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer.

Effect of variation of ABCB1 and GSTP1 on osteosarcoma survival after chemotherapy

J. Z. Li, Tian, Z. Q., Jiang, S. N., and Feng, T., Effect of variation of ABCB1 and GSTP1 on osteosarcoma survival after chemotherapy, vol. 13, pp. 3186-3192, 2014.

We conducted a comprehensive study to investigate the role of genes involved in metabolic and transport pathways in response to chemotherapy and clinical outcome of osteosarcoma patients. Genotyping of seven gene polymorphisms was performed on a 384-well plate format on the Sequenom MassARRAY platform in 162 patients with osteosarcoma. We studied the correlation of the seven gene polymorphisms with response to chemotherapy and clinical outcome of patients.

Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy

M. M. Silva, Da Fonseca, C. O., Moura-Neto, R., Carvalho, J. F., Quirico-Santos, T., and Carvalho, M. G., Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy, vol. 12, pp. 1621-1630, 2013.

GSTM1 (glutathione S-transferase mu 1) and GSTT1 (glutathione S-transferase theta 1) are critical enzymes for detoxification of endogenous and environmental carcinogens. Constitutive GST gene polymorphisms may be associated with increased risk for cancer development. We made an explorative study of a Brazilian population with malignant glioma to determine whether GSTM1 and GSTT1 genetic polymorphisms influence the response to intranasal administration of perillyl alcohol and the survival rate.

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