Glutathione reductase

Random amplified polymorphic DNA analysis of salt-tolerant tobacco mutants generated by gamma radiation

Ö. Çelik and Atak, Ç., “Random amplified polymorphic DNA analysis of salt-tolerant tobacco mutants generated by gamma radiation”, vol. 14, pp. 1324-1337, 2015.

Salinity is one of the major problems limiting the yield of agricultural products. Radiation mutagenesis is used to improve salt-tolerant mutant plants. In this study, we aimed to improve salt-tolerant mutants of two oriental tobacco varieties. One thousand seeds of each variety (M0) were irradiated with 100, 200, 300, and 400 Gy gamma rays by Cs-137 gamma. In the M1 generation, 2999 single plants were harvested. The next season, these seeds were bulked and planted to obtain M2 progeny. The seeds of 1900 M2 plants were picked separately.

Protective effects of ascorbic acid and vitamin E on antioxidant enzyme activity of freeze-thawed semen of Qinchuan bulls

X. L. Zhao, Li, Y. K., Cao, S. J., Hu, J. H., Wang, W. H., Hao, R. J., Gui, L. S., and Zan, L. S., “Protective effects of ascorbic acid and vitamin E on antioxidant enzyme activity of freeze-thawed semen of Qinchuan bulls”, vol. 14, pp. 2572-2581, 2015.

The aim of this study was to determine the protective effects of the combination of ascorbic acid (Vc) and vitamin E (VE) on antioxidant enzyme activity, sperm motility, viability, and acrosome integrity of Qinchuan bulls after freeze-thaw. In this study, we determined the effects of Vc and VE on the activity of the antioxidant enzyme defense system comprising glutathione peroxidase (GSH-Px), glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD). The combination of Vc and VE had protective effects on sperm motility and viability.

Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in amurine model

G. M. Chaves, MacCallum, D. M., Odds, F. C., and Bates, S., “Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in amurine model”, vol. 6, pp. 1051-1063, 2007.

Resistance of Candida albicans to reactive oxygen species is thought to enhance its virulence in mammalian hosts. Genes such as SOD1, which encodes the anti-oxidant, superoxide dismutase, are known virulence factors. We disrupted the gene GRX2, which encodes a putative glutathione reductase (glutaredoxin) in C. albicans, and we compared the mutant with an sod1Δmutant. In vitro, the grx2Δstrain, but not the sod1Δstrain, was defective in hypha formation.

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