Glucose and lipid metabolism

Effect of hypothalamic-pituitary-adrenal axis alterations on glucose and lipid metabolism in diabetic rats

M. W. Si, Yang, M. K., and Fu, X. D., Effect of hypothalamic-pituitary-adrenal axis alterations on glucose and lipid metabolism in diabetic rats, vol. 14, pp. 9562-9570, 2015.

This study investigated the relationship between alterations in the hypothalamic-pituitary-adrenal (HPA) axis function and glucose and lipid metabolism in diabetic rats. To accomplish this a diabetes model was established by jointly administering a long-term high-fat diet plus Streptozotocin (STZ; 50 mg/kg ip). The rats were randomly divided into four groups: 1) a normal control group, 2) a model group, 3) astragalus polysaccharide (APS) group, and 4) a metformin group. APS and metformin hydrochloride were administered intragastrically (100 mg∙kg-1d-1).

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