Glucocorticoids

Administration of low-dose cyclosporine alone for the treatment of elderly patients with membranous nephropathy

M. X. Li, Yu, Y. W., Zhang, Z. Y., Zhao, H. D., and Xiao, F. L., Administration of low-dose cyclosporine alone for the treatment of elderly patients with membranous nephropathy, vol. 14, pp. 2665-2673, 2015.

This study aimed to investigate the effects of administration of low-dose cyclosporine A (CsA) alone and the combination of low-dose CsA and a low-dose hormone for the treatment of elderly patients with membranous nephropathy. We divided 27 patients into two groups as follows: low-dose CsA group (group A) and the group receiving a combination of a low-dose hormone and low-dose CsA (group B). The treatment and follow-up times were ≥6 months.

Different magnitude of resistance to non-depolarizing muscle relaxants in dexamethasone-treated rat diaphragm associated with altered acetylcholine receptor expression

D. Chen, Yang, M. R., Huang, L. N., Qiu, Y. W., and Li, S. T., Different magnitude of resistance to non-depolarizing muscle relaxants in dexamethasone-treated rat diaphragm associated with altered acetylcholine receptor expression, vol. 13, pp. 5892-5900, 2014.

The aim of this study was to investigate the influence of chronic dexamethasone (Dex) administration on rat diaphragm sensitivity to non-depolarizing muscle relaxants (NDMRs) and muscular nicotinic acetylcholine receptor (nAChR) expression, which may help direct future administration of NDMRs. Adult male Sprague-Dawley rats were randomized to receive a daily intraperitoneal injection of Dex (600 μg/kg body mass) or an equivalent volume of saline (N = 20 in each group) for 14 days.

11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease

F. Atalar, Vural, B., Ciftci, C., Demirkan, A., Akan, G., Susleyici-Duman, B., Gunay, D., Akpinar, B., Sagbas, E., Ozbek, U., and Buyukdevrim, A. S., 11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease, vol. 11, pp. 3122-3132, 2012.

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) activity and mRNA levels are increased in visceral and subcutaneous adipose tissues of metabolic syndrome subjects. We analyzed 11β-HSD-1 expression in human epicardial adipose (EA) and ascending aorta (AA) tissues of metabolic syndrome patients and examined their contribution to the development of coronary atherosclerosis.

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