Glucocorticoid sensitivity inflammation

Quantitation of glucocorticoid receptor alpha and NF-κB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients

L. O. Cavalcante, Melo, M. R., Dinis, V. G., Castro, R. B., Souza, B. D. B., and Longui, C. A., Quantitation of glucocorticoid receptor alpha and NF-κB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients, vol. 9, pp. 2300-2310, 2010.

We measured NF-κB, IKK, c-Fos, and GRαmRNA expression and in vivo glucocorticoid sensitivity in patients with rheumatoid arthritis. A very low dose intravenous dexamethasone suppression test and real-time PCR quantitation of mRNA of these genes were performed on blood samples from 21 rheumatoid arthritis patients who were not on glucocorticoids during the previous four months and on blood samples from 20 healthy individuals.

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