Gibbs sampling

Identification of disturbed pathways in heart failure based on Gibbs sampling and pathway enrichment analysis

P. Chen, Guo, L. H., Guo, Y. K., Qu, Z. J., Gao, Y., Qiu, H., Chen, P., Guo, L. H., Guo, Y. K., Qu, Z. J., Gao, Y., and Qiu, H., “Identification of disturbed pathways in heart failure based on Gibbs sampling and pathway enrichment analysis”, vol. 15, p. -, 2016.

We identified disturbed pathways in heart failure (HF) based on Gibbs sampling combined with pathway enrichment analysis. A total of 396 Markov chains (MCs) (gene count >5) were obtained. After Gibbs sampling, six differentially expressed molecular functions (DEMFs) (possibility ≥0.8) were obtained. As statistical analysis was performed on the number of individual differentially expressed genes (DEGs), we found that there were 137 DEGs with frequency of occurrence ≥2 in the DEMFs.

Estimating the genetic parameters for liver fat traits in broiler lines divergently selected for abdominal fat

M. J. Liang, Wang, Z. P., Xu, L., Leng, L., Wang, S. Z., Luan, P., Cao, Z. P., Li, Y. M., and Li, H., “Estimating the genetic parameters for liver fat traits in broiler lines divergently selected for abdominal fat”, vol. 14, pp. 9646-9654, 2015.

Intensive selection of broilers for improved growth rate is known to exert a negative effect on broiler health, such as an increase in body fat (and its related diseases). Excessive fat deposition in the liver can cause fatty liver hemorrhagic syndrome (FLHS); in addition, traits associated with liver fat have also been associated with FLHS. This study explored the genetic relationships among liver fat-related traits. Data was collected from 462 birds derived from 16th generation Northeast Agricultural University broiler lines divergently selected for abdominal fat content.

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