Giant cell tumor

Potential role of heat-shock proteins in giant cell tumors

J. T. Chen, Younusi, A., Cao, L., Tian, Z., Zhou, Y. J., and Song, X. H., Potential role of heat-shock proteins in giant cell tumors, vol. 14, pp. 19144-19154, 2015.

We investigated the differential expression protein profile of giant cell tumors (GCTs), which can be used to monitor the tumor’s recurrence and metastasis, to provide preliminary results for further study. We also explored heat-shock protein (HSP) inhibitor that prevents tumors from recurring and migrating. A stable isotope-labeling strategy using isobaric tags for relative and absolute quantitation coupled with two-dimensional liquid chromatography tandem mass spectrometry was used to separate and identify differentially expressed proteins.

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