Gestational diabetes

Association between macrophage migration inhibitory factor rs1007888 and GDM

Y. Zhan, Li, C., Chen, J., Yu, S., Gao, Q., Wang, Y. P., and Liu, S. G., “Association between macrophage migration inhibitory factor rs1007888 and GDM”, vol. 14, pp. 797-804, 2015.

We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study.

Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control

H. R. Frigeri, Santos, I. C. R., Réa, R. R., Almeida, A. C. R., Fadel-Picheth, C. M. T., Pedrosa, F. O., Souza, E. M., Rego, F. G. M., and Picheth, G., “Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control”, vol. 11, pp. 1433-1441, 2012.

Glucokinase (GCK) plays a key role in glucose homeostasis. Gestational diabetes mellitus increases the risk of gestational complications in pregnant women and fetuses. We screened for mutations in coding and flanking regions of the GCK gene in pregnant women with or without gestational diabetes in a Brazilian population. A sample of 200 pregnant women classified as healthy (control, N = 100) or with gestational diabetes (N = 100) was analyzed for mutations in the GCK gene.

The functional polymorphisms -429T>C and -374T>A of the RAGE gene promoter are not associated with gestational diabetes in Euro-Brazilians

I. C. R. Santos, Daga, D. R., Frigeri, H. R., Réa, R. R., Almeida, A. C. R., Souza, E. M., Pedrosa, F. O., Fadel-Picheth, C. M. T., and Picheth, G., “The functional polymorphisms -429T>C and -374T>A of the RAGE gene promoter are not associated with gestational diabetes in Euro-Brazilians”, vol. 9. pp. 1130-1135, 2010.

The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have pro-inflammatory actions in human gestational tissues, increasing oxidative stress and the release of cytokines and prostaglandins.

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