Genotoxicity test

Elevated micronucleus frequencies in patients with pleural plaque secondary to environmental exposure to asbestos

M. Gövercin, Tomatir, A. G., Evyapan, F., Acikbas, I., Coşkun, G., and Akdag, B., Elevated micronucleus frequencies in patients with pleural plaque secondary to environmental exposure to asbestos, vol. 13, pp. 598-604, 2014.

We examined genotoxic damage and frequency of micronuclei in people living in the Bekilli and Suller districts of Denizli city who had been diagnosed with pleural plaques as a result of environmental exposure to asbestos. Peripheral blood samples were obtained from 30 volunteer patients 59-86 years old who did not smoke or consume alcohol and who were diagnosed with calcified pleural plaques. We also examined 30 healthy controls with similar features, who also lived in downtown Denizli. Micronucleus frequencies, nuclear division index, and mitotic index were determined.

Assessing the genotoxicities of sparteine and compounds isolated from Lupinus mexicanus and L. montanus seeds by using comet assay

M. R. Silva, Alvarez, C. M., García, P. M., and Ruiz, M. A., Assessing the genotoxicities of sparteine and compounds isolated from Lupinus mexicanus and L. montanus seeds by using comet assay, vol. 13, pp. 10510-10517, 2014.

The genus Lupinus is widely distributed. Its seeds are used for animal and human food, and Lupinus possesses pharmacological potential because of its high content of quinolizidine alkaloids and flavonoids; however, there is little available information about its genotoxicity. We used the comet assay and staminal nuclei of Tradescantia (clone 4430) to evaluate the in vitro genotoxicity of 4 concentrations (0.01, 0.1, 0.5, and 1.0 mM) of alkaloid extracts of Lupinus mexicanus and Lupinus montanus, flavonoids of L.

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