Genomics

Application of genomics and proteomics in drug target discovery

H. M. Zhang, Nan, Z. R., Hui, G. Q., Liu, X. H., and Sun, Y., Application of genomics and proteomics in drug target discovery, vol. 13, pp. 198-204, 2014.

Gene medicine is making breakthroughs in health questions that have baffled humanity for centuries. To understand and utilize gene medicine, it is necessary to realize its action against targets at the molecular level. Currently, many methods can be used to discover drug targets; among these, genomic and proteomic methods are the two most important. In this study, we introduced how to discover drug targets by genomic and proteomic methods in detail. These contents are beneficial for understanding and utilizing the two methods to discover new drug targets of gene medicine.

Application of functional genomic information to develop efficient EST-SSRs for the chicken (Gallus gallus)

M. R. Bakhtiarizadeh, Arefnejad, B., Ebrahimie, E., and Ebrahimi, M., Application of functional genomic information to develop efficient EST-SSRs for the chicken (Gallus gallus), vol. 11, pp. 1558-1574, 2012.

Many years of domestication and breeding have given rise to the wide range of chicken breeds that exist today; however, an increasing number of local chicken breeds are under threat of extinction. A comprehensive characterization of chicken markers (especially type I markers) is needed to monitor and conserve genetic diversity in this species. The explosion of genomics and functional genomics information in recent years has opened new possibilities for the generation of molecular markers.

Public sphere and the sustainability of the bioinformatics promise

M. Leite, Public sphere and the sustainability of the bioinformatics promise, vol. 3, pp. 575-581, 2004.

The literature about genomics and bioinformatics achievements in high-impact journals such as Nature and Science has raised disproportionate expectations amongst the general public about fast and revolutionary drugs and breakthroughs in biomedicine. However, the yield obtained by database mining activities has been modest, as reported in the February 2001 issues of these journals featuring the completion of human genome draft sequences by the Human Genome Project Consortium and the company Celera.

Update of microbial genome programs for bacteria and archaea

P. Borges San Celestino, de Carvalho, L. Rodrigues, de Freitas, L. Martins, Martins, N. Florêncio, Pacheco, L. Gustavo Ca, Miyoshi, A., Azevedo, V., and Dorella, F. Alves, Update of microbial genome programs for bacteria and archaea, vol. 3, pp. 421-431, 2004.

Since the Haemophilus influenzae genome sequence was completed in 1995, 172 other prokaryotic genomes have been completely sequenced, while 508 projects are underway. Besides pathogens, organisms important in several other fields, such as biotechnology and bioremediation, have also been sequenced. Institutions choose the organisms they wish to sequence according to the importance that these species represent to them, the availability of the microbes, and based on the similarity of a species of interest with others that have been sequenced previously.

Subscribe to Genomics