Genetics

Lack of differences in the expression of the angiotensin I - converting enzyme gene in the rotator muscles of patients with adolescent idiopathic scoliosis in a cross-sectional study comparing between the concave and convex sides of the scoliosis.

M. Wajchenberg, Martins, D. E., Luciano, R. P., Araujo, R. C., Schmidt, B., Oliveira, A. B. S., Puertas, E. B., Almeida, S. S., and Faloppa, F., “Lack of differences in the expression of the angiotensin I - converting enzyme gene in the rotator muscles of patients with adolescent idiopathic scoliosis in a cross-sectional study comparing between the concave and convex sides of the scoliosis.”, Genetics and Molecular Research, vol. 18, no. 2, 2019.

Common genetic risk factors of venous thromboembolism in Western and Asian populations

S. S. Huang, Liu, Y., Jing, Z. C., Wang, X. J., Mao, Y. M., Huang, S. S., Liu, Y., Jing, Z. C., Wang, X. J., and Mao, Y. M., “Common genetic risk factors of venous thromboembolism in Western and Asian populations”, vol. 15. p. -, 2016.

Venous thromboembolism (VTE) is a multifactorial disorder involving both acquired and genetic risk factors. The common genetic factors in Western populations have been studied and reported for several decades, while studies on Asian populations are relatively scarce. Evidence suggests that the prevalence and genetic risk factors of VTE vary significantly among ethnic populations. In this review, we summarize the common genetic risk factors of VTE in both Western and Asian populations.

An let-7 KRAS rs712 polymorphism increases hepatocellular carcinoma risk

D. Xiong, Song, Y. P., Xiong, W., and Liang, Y. D., “An let-7 KRAS rs712 polymorphism increases hepatocellular carcinoma risk”, vol. 14, pp. 14050-14055, 2015.

KRAS, also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, acts as an intracellular signal transducer. The oncogenic KRAS mutation is an essential step in the development of many types of human cancers, including hepatocellular carcinoma. Here we aimed to investigate the relationship between KRAS rs712 polymorphisms and hepatocellular carcinoma susceptibility. Five-hundred-and-fourteen participants were enrolled in a case-control study (262 cases and 252 normal subjects).

Correlation between natriuretic peptide receptor C (NPR3) gene polymorphisms and hypertension in the Dai people of China

H. Sun, Yang, Z. Q., Liu, S. Y., Yu, L., Huang, K., Lin, K. Q., Chu, J. Y., and Huang, X. Q., “Correlation between natriuretic peptide receptor C (NPR3) gene polymorphisms and hypertension in the Dai people of China”, vol. 14, pp. 8786-8795, 2015.

Hypertension affects one-fifth of the world population. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) that correlated with hyper­tension in large samples. However, the genetic mutations leading to hypertension might differ among various populations, as they have dif­ferent origins and are subjected to different environmental pressures. Therefore, additional studies are urgently needed to verify the GWAS findings across different populations.

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