Genetic variants

Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women

Z. Pan, Fu, Z., Song, Q., Cao, W., Cheng, W., Xu, X., Pan, Z., Fu, Z., Song, Q., Cao, W., Cheng, W., and Xu, X., Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women, vol. 15, p. -, 2016.

Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) in five hormone-related genes: estrogen receptor-α (ESR1), aromatase (CYP19), catechol-O-methyl transferase (COMT), sex hormone-binding globulin (SHBG), and glutathione S-transferase (GSTP1).

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