Genetic variability

Genetic variability of CYP3A4 in a heterogeneous Brazilian population from Maranhão

S. C. Moutinho Monteiro, de Sousa, I. H., Belfort, I. K. Pereira, Nunes, J. D., Penha, B. A. Sousa, M. Santos, dos, I. Louro, D., da Silva, I. D. C. Guerreiro, Monteiro, S. C. Moutinho, de Sousa, I. H., Belfort, I. K. Pereira, Nunes, J. D., Penha, B. A. Sousa, M. Santos, dos, I. Louro, D., and da Silva, I. D. C. Guerreiro, Genetic variability of CYP3A4 in a heterogeneous Brazilian population from Maranhão, vol. 15, p. -, 2016.

Inter-individual variability in drug metabolism may result in adverse drug responses. Pharmacogenetic studies have shown that polymorphisms in drug metabolizing enzymes may contribute to this variability. Among these enzymes, CYP3A4 is responsible for metabolizing over 50% of the clinically used drugs. The Brazilian population is composed of people with Native American, European, and African ancestries, and is therefore considered as one of the most intermixed populations in the world.

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