Genetic susceptibility

Association between the epithelial cadherin -160C/A gene polymorphism and diffuse gastric cancer risk: a meta-analysis

X. W. Chen, Sun, J. X., Wang, Z. N., Gao, P., Song, Y. X., Cao, J. F., Liu, B., and Xu, H. M., “Association between the epithelial cadherin -160C/A gene polymorphism and diffuse gastric cancer risk: a meta-analysis”, vol. 13, pp. 850-859, 2014.

Several previous studies have investigated whether the -160C/A epithelial cadherin promoter polymorphism confers an increased risk of diffuse gastric cancer (DGC), but conflicting results have been reported. To explore further the association of this polymorphism with DGC susceptibility, we performed an extensive search of relevant studies and conducted a meta-analysis to obtain a more precise estimate. We conducted a systematic literature search using the databases EMBASE, PubMed, and Web of Knowledge for reports published before August 2012 that met certain criteria.

Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control

H. R. Frigeri, Santos, I. C. R., Réa, R. R., Almeida, A. C. R., Fadel-Picheth, C. M. T., Pedrosa, F. O., Souza, E. M., Rego, F. G. M., and Picheth, G., “Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control”, vol. 11, pp. 1433-1441, 2012.

Glucokinase (GCK) plays a key role in glucose homeostasis. Gestational diabetes mellitus increases the risk of gestational complications in pregnant women and fetuses. We screened for mutations in coding and flanking regions of the GCK gene in pregnant women with or without gestational diabetes in a Brazilian population. A sample of 200 pregnant women classified as healthy (control, N = 100) or with gestational diabetes (N = 100) was analyzed for mutations in the GCK gene.

Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk

D. Y. Zhong, Chu, H. Y., Wang, M. L., Ma, L., Shi, D. N., and Zhang, Z. D., “Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk”, vol. 11, pp. 3490-3496, 2012.

The functional polymorphism Ser326Cys (rs1052133) in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in bladder cancer risk. However, reports of this association between the Ser326Cys polymorphism and bladder cancer risk are conflicting. In order to help clarify this relationship, we made a meta-analysis of seven case-control studies, summing 2521 cases and 2408 controls. We used odds ratios (ORs) with 95% confidence intervals (95%CIs) to assess the strength of the association.

Association of insulin growth factor-1 receptor gene polymorphisms with genetic susceptibility to idiopathic short stature

Y. Yang, Huang, H., Wang, W., Yang, L., Xie, L. L., and Huang, W., “Association of insulin growth factor-1 receptor gene polymorphisms with genetic susceptibility to idiopathic short stature”, vol. 12, pp. 4768-4779, 2013.

The association between single nucleotide polymorphisms (SNPs) in the insulin-like growth factor-1 receptor (IGF-1R) gene and susceptibility to idiopathic short stature (ISS) was investigated. Seven hundred and twelve Chinese children clinically diagnosed with ISS and 575 normal individuals were recruited between 2008 and 2011, and their SNPs were genotyped. Preliminary screening revealed that the rs1976667 and rs2684788 loci were significantly associated with genetic susceptibility to ISS (P = 0.03636 and P = 0.01352, respectively).

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