Genetic polymorphism

Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis

M. J. Ma, Liu, H. C., Qu, X. Q., and Wang, J. L., Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis, vol. 14, pp. 15652-15659, 2015.

Matrix metalloproteinase-3 (MMP-3) can mediate the occurrence and development of rheumatoid arthritis (RA). The MMP3 promoter gene exhibits polymorphism with 5A/6A alleles. We investigated the correlation between the expression of MMP3 gene polymorphism and RA to provide an objective basis for prognosis evaluation. We enrolled 80 RA patients and 80 healthy subjects.

Genetic polymorphism in sex hormone metabolism and prostate cancer risk

E. Ersekerci, Sofikerim, M., Taheri, S., Demirtas, A., and Halis, F., Genetic polymorphism in sex hormone metabolism and prostate cancer risk, vol. 14, pp. 7326-7334, 2015.

We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the study. Of these patients, 28 were diagnosed with benign prostatic hyperplasia and 32 with prostate cancer, while 30 subjects were included as a control group.

Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis

Y. Zhang, Yu, Y. F., Wang, J. Z., and Jia, H., Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis, vol. 14, pp. 8909-8918, 2015.

This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and screening, 9 eligible case-control studies were included in this meta-analysis.

Duplication polymorphisms in exon 4 of κ-casein gene in yak breeds/populations

S. Pingcuo, Gao, J., Jiang, Z. R., Jin, S. Y., Fu, C. Y., Liu, X., Huang, L., and Zheng, Y. C., Duplication polymorphisms in exon 4 of κ-casein gene in yak breeds/populations, vol. 14, pp. 10242-10248, 2015.

The objective of this study was to compare 12 bp-duplication polymorphisms in exon 4 of the κ-casein gene among 3 breeds/populations of yak (Bos grunniens). Genomic DNA was extracted from yak blood or muscle samples (N = 211) and a partial sequence of exon 4 of κ-casein gene was amplified by polymerase chain reaction. A polyacrylamide gel electrophoresis assay of the products (169 bp) revealed 2 variants. These variants differed in a 12-bp duplication of the nucleotide sequence corresponding to amino acids 147-150 (Glu-Ala-Ser-Pro) or 148-151 (Ala-Ser-Pro-Glu).

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