Genetic polymorphism

Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis

W. T. Yin, Pan, Y. P., Lin, L., Yin, W. T., Pan, Y. P., and Lin, L., Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis, vol. 15, p. -, 2016.

Genetic variations in human interleukin-1 (IL-1) genes are known to be involved in inflammatory disorders. The rs17561 and rs1143634 polymorphisms of IL-1α and IL-1β, respectively, have been increasingly recognized as important regulators in the development of periodontitis. However, the existence of a specific association remains controversial. Therefore, we performed a meta-analysis to explore the relationship between IL-1 polymorphism and periodontitis risk.

NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans

Q. Zhang, Fan, H. W., Zhang, J. Z., Wang, Y. M., and Xing, H. J., NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans, vol. 14, pp. 13968-13980, 2015.

Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase, CINAHL, Current Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu Journal.

Quantitative assessment of the association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive system cancer risk

J. Wang, Yang, S., Guo, F. H., Mao, X., Zhou, H., Dong, Y. Q., Wang, Z. M., and Luo, F., Quantitative assessment of the association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive system cancer risk, vol. 14, pp. 14291-14299, 2015.

The angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been reported to be associated with digestive system cancer; however, the results from previous studies have been conflicting. The present study aimed to investigate the association between the ACE I/D polymorphism and the risk of digestive system cancer using a meta-analysis of previously published studies. Databases were systematically searched to identify relevant studies published prior to December 2014. We estimated the pooled OR with its 95%CI to assess the association.

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