Genetic polymorphism

Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis

W. T. Yin, Pan, Y. P., Lin, L., Yin, W. T., Pan, Y. P., and Lin, L., Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis, vol. 15, p. -, 2016.

Genetic variations in human interleukin-1 (IL-1) genes are known to be involved in inflammatory disorders. The rs17561 and rs1143634 polymorphisms of IL-1α and IL-1β, respectively, have been increasingly recognized as important regulators in the development of periodontitis. However, the existence of a specific association remains controversial. Therefore, we performed a meta-analysis to explore the relationship between IL-1 polymorphism and periodontitis risk.

NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans

Q. Zhang, Fan, H. W., Zhang, J. Z., Wang, Y. M., and Xing, H. J., NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans, vol. 14, pp. 13968-13980, 2015.

Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase, CINAHL, Current Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu Journal.

Quantitative assessment of the association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive system cancer risk

J. Wang, Yang, S., Guo, F. H., Mao, X., Zhou, H., Dong, Y. Q., Wang, Z. M., and Luo, F., Quantitative assessment of the association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive system cancer risk, vol. 14, pp. 14291-14299, 2015.

The angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been reported to be associated with digestive system cancer; however, the results from previous studies have been conflicting. The present study aimed to investigate the association between the ACE I/D polymorphism and the risk of digestive system cancer using a meta-analysis of previously published studies. Databases were systematically searched to identify relevant studies published prior to December 2014. We estimated the pooled OR with its 95%CI to assess the association.

Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis

M. J. Ma, Liu, H. C., Qu, X. Q., and Wang, J. L., Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis, vol. 14, pp. 15652-15659, 2015.

Matrix metalloproteinase-3 (MMP-3) can mediate the occurrence and development of rheumatoid arthritis (RA). The MMP3 promoter gene exhibits polymorphism with 5A/6A alleles. We investigated the correlation between the expression of MMP3 gene polymorphism and RA to provide an objective basis for prognosis evaluation. We enrolled 80 RA patients and 80 healthy subjects.

Genetic polymorphism in sex hormone metabolism and prostate cancer risk

E. Ersekerci, Sofikerim, M., Taheri, S., Demirtas, A., and Halis, F., Genetic polymorphism in sex hormone metabolism and prostate cancer risk, vol. 14, pp. 7326-7334, 2015.

We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the study. Of these patients, 28 were diagnosed with benign prostatic hyperplasia and 32 with prostate cancer, while 30 subjects were included as a control group.

Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis

Y. Zhang, Yu, Y. F., Wang, J. Z., and Jia, H., Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis, vol. 14, pp. 8909-8918, 2015.

This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and screening, 9 eligible case-control studies were included in this meta-analysis.

Duplication polymorphisms in exon 4 of κ-casein gene in yak breeds/populations

S. Pingcuo, Gao, J., Jiang, Z. R., Jin, S. Y., Fu, C. Y., Liu, X., Huang, L., and Zheng, Y. C., Duplication polymorphisms in exon 4 of κ-casein gene in yak breeds/populations, vol. 14, pp. 10242-10248, 2015.

The objective of this study was to compare 12 bp-duplication polymorphisms in exon 4 of the κ-casein gene among 3 breeds/populations of yak (Bos grunniens). Genomic DNA was extracted from yak blood or muscle samples (N = 211) and a partial sequence of exon 4 of κ-casein gene was amplified by polymerase chain reaction. A polyacrylamide gel electrophoresis assay of the products (169 bp) revealed 2 variants. These variants differed in a 12-bp duplication of the nucleotide sequence corresponding to amino acids 147-150 (Glu-Ala-Ser-Pro) or 148-151 (Ala-Ser-Pro-Glu).

Subscribe to Genetic polymorphism