Genetic polymorphism

Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development

T. Zara-Lopes, Gimenez-Martins, A. P. A., Nascimento-Filho, C. H. V., Castanhole-Nunes, M. M. U., Galbiatti-Dias, A. L. S., Padovani-Júnior, J. A., Maniglia, J. V., Francisco, J. L. E., Pavarino, E. C., Goloni-Bertollo, E. M., Zara-Lopes, T., Gimenez-Martins, A. P. A., Nascimento-Filho, C. H. V., Castanhole-Nunes, M. M. U., Galbiatti-Dias, A. L. S., Padovani-Júnior, J. A., Maniglia, J. V., Francisco, J. L. E., Pavarino, E. C., and Goloni-Bertollo, E. M., Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development, vol. 15, p. -, 2016.

Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR A2756G, rs1805087) polymorphisms and risk for thyroid and breast cancer.

Study of the relationship between IL-10 polymorphism and serum lipoprotein levels in Han Chinese individuals

W. Q. Yang and Yang, W. Q., Study of the relationship between IL-10 polymorphism and serum lipoprotein levels in Han Chinese individuals, vol. 15, p. -, 2016.

Previous studies have shown that cytokines can affect serum lipoprotein concentrations. The aim of this study was to examine the association between IL-10 gene polymorphisms and serum lipoprotein levels of Han Chinese individuals. A total of 359 Han Chinese people were enrolled in this investigation. IL-10 -592, -819, and -1082 genotypes were established using polymerase chain reaction-restriction fragment length polymorphism analysis.

Isolation and characterization of polymorphic microsatellite markers for blue fox (Alopex lagopus)

Y. M. Li, Guo, P. C., Lu, J. Y., Bai, C. Y., Zhao, Z. H., Yan, S. Q., Li, Y. M., Guo, P. C., Lu, J. Y., Bai, C. Y., Zhao, Z. H., and Yan, S. Q., Isolation and characterization of polymorphic microsatellite markers for blue fox (Alopex lagopus), vol. 15, p. -, 2016.

The blue fox, belonging to the family Canidae, is a coat color variant of the native arctic fox (Alopex lagopus). To date, microsatellite loci in blue fox are typically amplified using canine simple sequence repeat primers. In the present study, we constructed an (AC)n enrichment library, and isolated and identified 17 polymorphic microsatellite markers for blue fox. The number of alleles per locus is from two to seven based on 24 examined individuals.

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