Genes

Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development

T. Zara-Lopes, Gimenez-Martins, A. P. A., Nascimento-Filho, C. H. V., Castanhole-Nunes, M. M. U., Galbiatti-Dias, A. L. S., Padovani-Júnior, J. A., Maniglia, J. V., Francisco, J. L. E., Pavarino, E. C., Goloni-Bertollo, E. M., Zara-Lopes, T., Gimenez-Martins, A. P. A., Nascimento-Filho, C. H. V., Castanhole-Nunes, M. M. U., Galbiatti-Dias, A. L. S., Padovani-Júnior, J. A., Maniglia, J. V., Francisco, J. L. E., Pavarino, E. C., and Goloni-Bertollo, E. M., Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development, vol. 15, p. -, 2016.

Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR A2756G, rs1805087) polymorphisms and risk for thyroid and breast cancer.

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