Gene polymorphisms

Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea

Y. Zhang, Li, N. - F., Abulikemu, S., Zhang, D. - L., Wang, Y. - C., Kong, J. - Q., Nuer, G. - L., Yan, Z. - T., Li, H. - J., Zhang, J. - H., and Zhang, X. - Y., Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea, vol. 14, pp. 6733-6743, 2015.

Recent data have indicated that inflammation may have an important correlation with obstructive sleep apnea (OSA). Studies have indicated a relationship between OSA and TNF-α gene polymorphisms. Zinc finger protein 36 (ZFP36) regulates TNF-α mRNAs. However, ZFP36 gene polymorphisms have not been investigated in OSA. Therefore, we conducted the present case-control study to assess whether variances in ZFP36 gene polymorphisms account for differences in TNF-α levels in patients with moderate-to-severe OSA.

RANTES gene polymorphisms (-403G>A and -28C>G) associated with hepatitis B virus infection in a Saudi population

A. Al-Qahtani, Alarifi, S., Al-Okail, M., Hussain, Z., Abdo, A., Sanai, F., Al-Anazi, M., Khalaf, N., Al-Humaidan, H., Al-Ahdal, M., and Almajhdi, F. N., RANTES gene polymorphisms (-403G>A and -28C>G) associated with hepatitis B virus infection in a Saudi population, vol. 11, pp. 855-862, 2012.

Besides the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. “Regulated on activation normal T-cell expressed and secreted” factor (RANTES) plays a vital role in CD4+, CD8+ T-lymphocyte and dendritic cell activation and proliferation in inflammation. Single nucleotide polymorphisms (SNPs) in the RANTES gene are associated with several viral and non-viral diseases.

CASP-9 gene functional polymorphisms and cancer risk: A large-scale association study plus meta-analysis

Z. Y. Zhang, Xuan, Y., Jin, X. Y., Tian, X., and Wu, R., CASP-9 gene functional polymorphisms and cancer risk: A large-scale association study plus meta-analysis, vol. 12, pp. 3070-3078, 2013.

We investigated the association between CASP-9 polymorphisms and susceptibility to neoplasm. Fourteen studies with a total of 2733 neoplasm cases and 3352 healthy controls were included. Meta-analysis showed that the rs4645981*T allele and the rs4645981*T allele carrier were positively associated with neoplasm susceptibility [odds ratio (OR) = 1.43, 95% confidence interval (95%CI) = 1.12-1.81, P = 0.004; OR = 1.46, 95%CI = 1.10-1.93, P = 0.009, respectively].

A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer

Z. Y. Zhang, Xuan, Y., Jin, X. Y., Tian, X., and Wu, R., A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer, vol. 12, pp. 3057-3069, 2013.

The caspase (CASP) gene family is known to be involved in apoptosis, cytokine maturation, cell growth, and differentiation. A large number of single nucleotide polymorphisms (SNPs) in the CASP gene family have been increasingly recognized as important regulators in the development of lung cancer. However, this specific association is still controversial. In this Human Genome Epidemiology review and meta-analysis, we summarized the available evidence associating lung cancer with the CASP gene family.

‘Ovar-Mhc’ - ovine major histocompatibility complex: structure and gene polymorphisms

V. S. R. Dukkipati, Blair, H. T., Garrick, D. J., and Murray, A., ‘Ovar-Mhc’ - ovine major histocompatibility complex: structure and gene polymorphisms, vol. 5. pp. 581-608, 2006.

The major histocompatibility complex (MHC) in sheep, Ovar-Mhc, is poorly characterised, when compared to other domestic animals. However, its basic structure is similar to that of other mammals, comprising class I, II and III regions. Currently, there is evidence for the existence of four class I loci. The class II region is better characterised, with evidence of one DRA, four DRB (one coding and three non-coding), one DQA1, two DQA2, and one each of the DQB1, DQB2, DNA, DOB, DYA, DYB, DMA, and DMB genes in the region.

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