Gene polymorphism

Polymorphism and haplotype analyses of swine leukocyte antigen DQA exons 2, 3, 4, and their associations with piglet diarrhea in Chinese native pig

X. Y. Huang, Yang, Q. L., Yuan, J. H., and Gun, S. B., Polymorphism and haplotype analyses of swine leukocyte antigen DQA exons 2, 3, 4, and their associations with piglet diarrhea in Chinese native pig, vol. 14, pp. 10461-10472, 2015.

In this study, 290 Chinese native Yantai black pig piglets were investigated to identify gene polymorphisms, for haplotype reconstruction, and to determine the association between piglet diarrhea and swine leukocyte antigen (SLA) class II DQA exons 2, 3, and 4 by polymerase chain reaction-single stranded conformational polymorphism and cloning sequencing.

Arg188His polymorphism in the XRCC2 gene and the risk of ovarian cancer: a meta-analysis

M. Zhai, Wang, Y., and Jiang, M. F., Arg188His polymorphism in the XRCC2 gene and the risk of ovarian cancer: a meta-analysis, vol. 14, pp. 10808-10815, 2015.

Numerous studies have evaluated the association between the Arg188His polymorphism of the X-ray repair cross-complementing group 2 (XRCC2) gene and ovarian cancer risk. However, the specific association is still controversial. This meta-analysis was therefore designed to clarify these controversies. Relevant case-control studies were enrolled in the meta-analysis. Quality evaluation of the included studies was conducted by two physicians. Statistical analyses were carried out using the Stata 12.0 software for meta-analysis.

Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis

Y. L. Wang, Kong, H., Xie, W. P., and Wang, H., Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis, vol. 14, pp. 10774-10785, 2015.

Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the association between VDBP gene polymorphism and COPD. After qualitative evaluation, randomized controlled trials were pooled using either a fixed- or a random-effect model depending upon the degree of heterogeneity.

COL1A1 gene -1997G/T polymorphism and risk of osteoporosis in postmenopausal women: a meta-analysis

K. H. Yu, Tang, J., Dai, C. Q., Yu, Y., and Hong, J. J., COL1A1 gene -1997G/T polymorphism and risk of osteoporosis in postmenopausal women: a meta-analysis, vol. 14, pp. 10991-10998, 2015.

Studies investigating the association between the COL1A1 gene -1997G/T polymorphism and the risk of osteoporosis in postmenopausal women have reported conflicting results. We performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. We conducted searches of the published literature in the PubMed and Embase databases up to September 2014. We estimated the pooled odds ratios with their 95% confidence intervals to assess the associations using fixed- or random-effect models.

Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population

X. P. Hu, Li, Z. Q., Zhou, J. Y., Yu, Z. H., Zhang, J. M., and Guo, M. L., Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population, vol. 14, pp. 11631-11638, 2015.

Environmental influences on the development and progression of dental caries are well known; however, there is little evidence of a genetic component imparting susceptibility to dental caries. The aim of this study was to investigate the relationship between a single nucleotide polymorphism in the vitamin D receptor TaqI locus and dental caries susceptibility in a Chinese population.

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