Gene polymorphism

729G/C polymorphism in Toll-like receptor 4 results in increased susceptibility to bladder cancer

B. Wan, Tan, J., Zeng, Q., He, L. Y., Gan, Y., Dai, Y. B., and Yao, K., 729G/C polymorphism in Toll-like receptor 4 results in increased susceptibility to bladder cancer, vol. 14, pp. 15482-15487, 2015.

In this study, the association between the 729G/C polymorphism in Toll-like receptor 4 (TLR4) and the risk of bladder cancer was investigated. A total of 376 patients with bladder cancer and 380 healthy volunteers from the Third Xiangya Hospital of Central South University (China) were enrolled in this study between January 2008 and February 2014. The TLR4-729G/C polymorphism was detected by the polymerase chain reaction-restriction fragment length polymorphism assay.

Correlation analysis between the delayed rectifier potassium channel KCNE1 (G38S) polymorphism and atrial fibrillation among the senior Uygur population in Xinjiang

N. Wugeti, Yu-Jun, G., Juan, S., and Mahemuti, A., Correlation analysis between the delayed rectifier potassium channel KCNE1 (G38S) polymorphism and atrial fibrillation among the senior Uygur population in Xinjiang, vol. 14, pp. 15906-15912, 2015.

Current resources to support genetic screening among the Uygur population in Xinjiang territory for atrial fibrillation (AF) have not been well established and large-scale epidemiological analyses are needed. Using patients from the Xinjiang Uygur population as subjects, and the delayed rectifier potassium channel KCNE1 and its associated polymorphism G38S (rs1805127) as the candidate gene, we analyzed the correlation between the G38S polymorphism and AF among the senior Uygur population in Xinjiang Province.

A study of the association between the connexin 40 rs35594137 polymorphism and atrial fibrillation in Xinjiang Chinese Han and Uygur populations

Y. Feng, Sun, J., Wang, L., and Hou, X. L., A study of the association between the connexin 40 rs35594137 polymorphism and atrial fibrillation in Xinjiang Chinese Han and Uygur populations, vol. 14, pp. 15705-15712, 2015.

Atrial fibrillation (AF) occurrence has a known genetic component. Many reports have revealed a correlation between gene mutation and AF, involving genes related to ion channels, connexin (Cx), and those within the angiotensin system. In this study, the cor­relation between the Cx 40 polymorphism (rs35594137) and AF was investigated in patients with AF in the Xinjiang, Turpan, and Kashi re­gions and in controls. The AF cohort included 122 patients (58 Han and 64 Uygur). The control subjects were recruited according to the 1:1 corresponding method and matched for age and gender.

Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey

N. K. Turhan, S. Ilikhan, U., Hamamcioglu, A. C., Ustundag, Y., Dursun, A., and Kokturk, F., Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey, vol. 14, pp. 17079-17090, 2015.

Chronic viral hepatitis B, chronic viral hepatitis C, non-alcoholic steatohepatitis, alcoholic liver disease, autoimmune hepatitis, primary biliary cirrhosis, and secondary biliary cirrhosis are important health issues worldwide. While an association between angiotensin-converting enzyme gene insertion/deletion (ACE gene I/D) polymorphism and liver fibrosis has been demonstrated in rat studies, the results of clinical studies area have been contradictory.

Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer

J. P. Kleine, Camargo-Kosugi, C. M., Carvalho, C. V., Silva, F. C., and Silva, I. D. C. G., Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer, vol. 14, pp. 18965-18973, 2015.

The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer.

Interaction of the CYP1A1 gene polymorphism and smoking in non-small cell lung cancer susceptibility

Y. Q. Xie, Chen, J. M., and Liu, Y., Interaction of the CYP1A1 gene polymorphism and smoking in non-small cell lung cancer susceptibility, vol. 14, pp. 19411-19417, 2016.

Many studies have shown that genetic factors, environmental factors, and bad living habits, especially smoking, are risk factors for lung cancer. However, not all smokers develop lung cancer, which may be related to different genetic backgrounds. Currently, most research has investigated the GSTM1, XRCC1, XRCC3, CYP2D6, and C188T genes. Little research has been done on the cytochrome P450 (CYP) 1A1 gene, and results have varied.

TGF-β1 polymorphisms and familial aggregation of liver cancer in Guangxi, China

P. Q. Wan, Wu, J. Z., Huang, L. Y., Wu, J. L., Wei, Y. H., and Ning, Q. Y., TGF-β1 polymorphisms and familial aggregation of liver cancer in Guangxi, China, vol. 14, pp. 8147-8160, 2015.

The goal of present study was to investigate the relationship between polymorphisms of TGF-β1 and familial aggregation of liver cancer in Guangxi Zhuang, Han, and Yao populations. We conducted a population-based case-control family study of liver cancer in Guanxi, China. A total of 214 individuals from 37 case families were surveyed for polymorphisms in TGF-β1. We genotyped six functional TGF-β1 polymorphisms: rs1800469, rs2241715, rs2241716, rs11466345, rs8105161, and rs747857.

Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: a meta-analysis

J. A. Zhang, Li, J. R., and Qiao, Y. J., Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: a meta-analysis, vol. 14, pp. 9163-9170, 2015.

The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using meta‑analysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Statistical analysis was performed using the STATA 12.0 software.

Relationship of the APOA5/A4/C3/A1 gene cluster and APOB gene polymorphisms with dyslipidemia

H. J. Ou, Huang, G., Liu, W., Ma, X. L., Wei, Y., Zhou, T., and Pan, Z. M., Relationship of the APOA5/A4/C3/A1 gene cluster and APOB gene polymorphisms with dyslipidemia, vol. 14, pp. 9277-9290, 2015.

We determined the alleles of ten single nucleotide poly­morphisms (SNPs) in the APOA5/A4/C3/A1 gene cluster and in APOB in Han Chinese from Xinjiang Shihezi, China using MALDI-TOF mass spectrometry, and explored the correlation between these SNPs and dyslipidemia through a case-control study design with 250 pa­tients and 250 normal controls. All SNPs except for APOA5 rs2072560 conformed to Hardy-Weinberg equilibrium (all P > 0.05).

Association between the XRCC1 Arg399Gln polymorphism and risk of cervical carcinoma: a meta-analysis

D. Y. Liu, Liang, H. C., and Xiao, X. M., Association between the XRCC1 Arg399Gln polymorphism and risk of cervical carcinoma: a meta-analysis, vol. 14, pp. 9821-9828, 2015.

Numerous studies have evaluated the association between Arg399Gln polymorphism of DNA repair gene XRCC1 and cervical carcinoma risk. However, the specific association is still controversial. To assess the relationship between XRCC1 Arg399Gln polymorphism and cervical carcinoma, we conducted a comprehensive meta-analysis of 10 case-control studies with 2051 cervical carcinoma cases and 2919 controls.

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