Gene polymorphism

Relationship between 5-HTTLPR polymorphism and post-stroke depression

W. Y. Guo, Zhang, Z. H., Mu, J. L., Liu, D., Zhao, L., Yao, Z. Y., Song, J. G., Guo, W. Y., Zhang, Z. H., Mu, J. L., Liu, D., Zhao, L., Yao, Z. Y., and Song, J. G., Relationship between 5-HTTLPR polymorphism and post-stroke depression, vol. 15, p. -, 2016.

Post-stroke depression (PSD) is a mental illness characterized by subjective feelings of depression, cognitive dysfunction, and decreased interest. The serotoninergic system is involved in the pathogenesis of depressive disorders and is regulated by the serotonin transporter gene. The serotonin transporter-linked polymorphic region (5-HTTLPR) has been examined as a factor associated with depression and other mental disorders. This study was performed to explore the relationship between 5-HTTLPR and PSD in a Han Chinese population.

Association between the interleukin-6-174 G/C polymorphism and risk of ischemic stroke: a meta-analysis

X. F. Jin, Wang, D. L., Zhou, Y., and Xiong, H., Association between the interleukin-6-174 G/C polymorphism and risk of ischemic stroke: a meta-analysis, vol. 14, pp. 13076-13083, 2015.

Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase databases were retrieved. Pooled ORs with 95%CIs were calculated using fixed- or random-effect models.

Correlation between the development of calcium oxalate stones and polymorphisms in the fibronectin gene in the Uighur population of the Xinjiang region of China

M. Murat, Aekeper, A., Yuan, L. Y., Alim, T., Du, G. J., Abdusamat, A., Wu, G. W., and Aniwer, Y., Correlation between the development of calcium oxalate stones and polymorphisms in the fibronectin gene in the Uighur population of the Xinjiang region of China, vol. 14, pp. 13728-13734, 2015.

Here, we have investigated the correlation between calcium oxalate stone formation and Fn gene polymorphisms in urinary calculi patients among the Uighur population (Xinjiang region). In this case control study, genomic DNA extracted from the peripheral blood of 129 patients with calcium oxalate stones (patient group) and 94 normal people (control group) was used to genotype polymorphisms in the rs6725958, rs10202709, and rs35343655 sites of the Fn gene by polymerase chain reaction-restriction fragment length polymorphism.

Correlation between polymorphisms of hypoxia-inducible factor-1α Pro582Ser and type 2 diabetic nephropathy

Y. X. Bi, Yu, L., and Jin, G. X., Correlation between polymorphisms of hypoxia-inducible factor-1α Pro582Ser and type 2 diabetic nephropathy, vol. 14, pp. 14503-14509, 2015.

We examined the correlation between gene polymorphisms in hypoxia-inducible factor-1α (HIF-1α) Pro582Ser and type 2 diabetic nephropathy (DN). A total of 244 subjects with type 2 diabetes were recruited. The 1285-bp locus polymorphism of HIF-1α exon was detected using polymerase chain reaction-restriction fragment length polymorphism. C/T single nucleotide polymorphisms were detected at the site of 1285 bp of the HIF-1α exon, from a proline to a serine (Pro582Ser). The frequency of CT heterozygotes was significantly higher in DN patients than in diabetes patients (P

Association of the CYP4F2 rs2108622 genetic polymorphism with hypertension: a meta-analysis

X. - H. Luo, Li, G. - R., and Li, H. - Y., Association of the CYP4F2 rs2108622 genetic polymorphism with hypertension: a meta-analysis, vol. 14, pp. 15133-15139, 2015.

Previous case-control studies on the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension have produced contrasting results. In this study, we aimed to further evaluate the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension. We selected four case-control studies related to the CYP4F2 gene rs2108622 polymorphism and hypertension by searching PubMed, EMBase, the Chinese Biomedical Literature Database, and the Wanfang database.

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