Gene density

Evaluating the annotation of protein-coding genes in bacterial genomes: Chloroflexus aurantiacus strain J-10-fl and Natrinema sp J7-2 as case studies

H. X. Zhang, Li, S. J., and Zhou, H. Q., Evaluating the annotation of protein-coding genes in bacterial genomes: Chloroflexus aurantiacus strain J-10-fl and Natrinema sp J7-2 as case studies, vol. 13, pp. 10891-10897, 2014.

Gene annotation plays a key role in subsequent biochemical and molecular biological studies of various organisms. There are some errors in the original annotation of sequenced genomes because of the lack of sufficient data, and these errors may propagate into other genomes. Therefore, genome annotation must be checked from time to time to evaluate newly accumulated data.

Increased gene coverage and Alu frequency in large linkage disequilibrium blocks of the human genome

Y. Wang, Fong, P. Y., Leung, F. C. C., Mak, W., and Sham, P. C., Increased gene coverage and Alu frequency in large linkage disequilibrium blocks of the human genome, vol. 6, pp. 1131-1141, 2007.

The human genome has linkage disequilibrium (LD) blocks, within which single-nucleotide polymorphisms show strong association with each other. We examined data from the International HapMap Project to define LD blocks and to detect DNA sequence features inside of them. We used permutation tests to determine the empirical significance of the association of LD blocks with genes and Alu repeats.

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