Gastric cancer

Bioinformatics analysis with graph-based clustering to detect gastric cancer-related pathways

P. Liu, Wang, X., Hu, C. H., and Hu, T. H., Bioinformatics analysis with graph-based clustering to detect gastric cancer-related pathways, vol. 11, pp. 3497-3504, 2012.

Despite a dramatic reduction in incidence and mortality rates, gastric cancer still remains one of the most common malignant tumors worldwide, especially in China. We sought to identify a set of discriminating genes that could be used for characterization and prediction of response to gastric cancer. Using bioinformatics analysis, two gastric cancer datasets, GSE19826 and GSE2685, were merged to find novel target genes and domains to explain pathogenesis; we selected differentially expressed genes in these two datasets and analyzed their correlation in order to construct a network.

Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis

B. M. Liu, Liu, T. M., You, B. S., You, H. Y., Yang, J., Li, L., and He, Y. C., Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis, vol. 11, pp. 3852-3860, 2012.

Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association.

Epstein-Barr virus DNA associated with gastric adenocarcinoma and adjacent non-cancerous mucosa in patients from Manaus, Brazil

P. F. de Aquino, Carvalho, P. C., Fischer, J. Sda Gama, de Souza, A. Q. L., Viana, J. S., Chalub, S. R. S., de Souza, A. D. L., and Carvalho, M. G. C., Epstein-Barr virus DNA associated with gastric adenocarcinoma and adjacent non-cancerous mucosa in patients from Manaus, Brazil, vol. 11, pp. 4442-4446, 2012.

Gastric cancer is one of most frequent causes of death in Brazil. The city of Manaus has one of the highest incidences of this disease in Brazil. The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that is classified as a group 1 carcinogen by the International Agency for Research on Cancer. We obtained biopsies from 6 control subjects and 10 patients with gastric carcinomas living in Manaus. In the patients, the samples were taken from tumors and from adjacent non-cancerous mucosa.

MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation

W. Peng, Chen, Z. - Y., Wang, L., Wang, Z., and Li, J., MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation, vol. 12, pp. 3038-3047, 2013.

MicroRNAs (miRNAs) are small non-coding RNAs that regulate the translation of targeted mRNAs. An increasing amount of evidence indicates that miRNAs play important role in cancer pathogenesis, apoptosis, proliferation, and differentiation as oncogenes or tumor suppressors. Recently, miRNA-199a has been shown to be involved in many human cancers, although the role of miRNA-199a-3p in gastric cancer has not yet been evaluated. In the present study, the expression of miRNA-199a-3p was found to be significantly downregulated in human gastric cancer tissues and cells.

HMGB3 characterization in gastric cancer

Y. Gong, Cao, Y., Song, L., Zhou, J., Wang, C., and Wu, B., HMGB3 characterization in gastric cancer, vol. 12, pp. 6032-6039, 2013.

Gastric cancer is a major health problem worldwide; it is the second most common cause of cancer death in the world. Recent studies indicate that the high-mobility group (HMG) of chromosomal proteins is associated with cancer progression. However, HMGB3 has been little studied. We analyzed the co-expression network between HMGB3 and differentially-expressed genes in the GSE17187 database, identifying the relevant transcription factors, and the conserved domain of HMGB3 to understand the underlying regulation mechanisms involved in gastric cancer.

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