Gastric cancer

IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis

Z. Li, Liu, Y., Cao, D., Jiang, M., and Luo, F., IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis, vol. 14, pp. 7008-7017, 2015.

We conducted a meta-analysis of eligible studies to estimate the association between gastric cancer risk and rs2275913G>A IL-17A and rs763780T>C IL-17F polymorphisms. We searched the relevant studies in both Chinese and English through PubMed, the Web of Science, the Cochrane Library, and EMBASE up to January 1, 2014, including 3939 cases and 5407 controls. Seven eligible case-control studies were selected, including seven studies on rs2275913G>A IL-17A and four studies on rs763780T>C IL-17F.

Pharmacogenetic role of XRCC1 polymorphisms on the clinical outcome of gastric cancer patients with platinum-based chemotherapy: a systematic review and meta-analysis

J. Xu, Ma, J., Zong, H. T., Wang, S. Y., and Zhou, J. W., Pharmacogenetic role of XRCC1 polymorphisms on the clinical outcome of gastric cancer patients with platinum-based chemotherapy: a systematic review and meta-analysis, vol. 13, pp. 1438-1446, 2014.

It is still controversial whether X-ray repair cross-complementing group (XRCC1) gene polymorphisms (Arg194Trp and Arg399Gln) are associated with the clinical outcome of platinum-based chemotherapy in gastric cancer patients based on published studies. Meta-analysis was performed to provide a systematic review of the findings. Eligible articles from the PubMed, SinoMed, and CNKI databases before September 1, 2012, were selected.

Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer

J. Lin, Zeng, R. M., Li, R. N., and Cao, W. H., Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer, vol. 13, pp. 2060-2068, 2014.

Epidemiological studies have indicated that folate metabolism is correlated with increased risk of gastric cancer. Since methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, in this study, we examined whether polymorphisms and haplotypes of MTHFR are correlated with the risk of gastric cancer. The polymorphisms MTHFR C677T and MTHFR A1298C were genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis in 285 patients and 570 healthy controls.

Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population

C. - P. Zhou, Pan, H. - Z., Li, F. - X., Hu, N. - Y., Li, M., and Yang, X. - X., Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population, vol. 13, pp. 3673-3680, 2014.

Evidence suggests that some genetic variants are risk factors for both colorectal cancer (CRC) and gastric cancer (GC). Thus, we selected 12 reported single nucleotide polymorphisms (SNPs) from genome-wide association studies of CRC and conducted this case-control study to assess the associations between these SNPs and the risk for GC in a southern Chinese population. All SNPs were genotyped in 249 individuals with GC and 292 healthy population-matched subjects using the Sequenom MassArray iPLEX System.

Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer

J. Jin, Xie, L., Xie, C. H., and Zhou, Y. F., Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer, vol. 13, pp. 4140-4145, 2014.

We aimed to explore the association between aberrant DNA methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) and human mutL homolog 1 (hMLH1) genes with gastric cancer. A total of 283 gastric cancer patients who were confirmed by pathological diagnosis were included in our study. Aberrant DNA methylation of MGMT and hMLH1 were detected. The proportions of DNA hypermethylation in MGMT and hMLH1 in cancer tissues were significantly higher than those in remote normal-appearing tissues.

Interleukin-1B-31 gene polymorphism in Hakka gastric cancer patients in Guangdong, China

B. Qiu, Zou, H. - Y., Yang, Y. - H., and Lai, C. - F., Interleukin-1B-31 gene polymorphism in Hakka gastric cancer patients in Guangdong, China, vol. 13, pp. 5873-5879, 2014.

The aim of this study was to examine the interleukin-1B (IL-1B) gene promoter region -31 (IL-1B-31) polymorphism distribution characteristic of Hakka gastric cancer patients in Guangdong Province and to explore its association with gastric cancer. We used the 1:1 case-control method, matrix-assisted laser desorption ionization flight time mass spectrometry, and MassARRAY-IPLEX technology to genotype IL-1B-31 (-31C> T) in 52 Hakka gastric cancer patients and 52 Hakka control subjects in Meizhou.

Inhibitory effect of survivin-targeting small interfering RNA on gastric cancer cells

Y. H. Li, Chen, M., Zhang, M., Zhang, X. Q., Zhang, S., Yu, C. G., Xu, Z. M., and Zou, X. P., Inhibitory effect of survivin-targeting small interfering RNA on gastric cancer cells, vol. 13, pp. 6786-6803, 2014.

A pair of inverted repeated sequences of the gene survivin was designed for stable double-stranded RNA establishment. After stable transfection, the biological behaviors of gastric cancer cells were observed. The interference rates of survivin-targeting siRNA (siRNA-survivin) in BGC823, MKN45, SGC7901, and cisplatin-resistant SGC7901 groups were 55.363 ± 3.974, 71.433 ± 3.774, 69.433 ± 7.336, and 76.767 ± 3.541%, respectively, compared with those in the control group.

Association of MLL3 expression with prognosis in gastric cancer

B. Li, Liu, H. Y., Guo, S. H., Sun, P., Gong, F. M., and Jia, B. Q., Association of MLL3 expression with prognosis in gastric cancer, vol. 13, pp. 7513-7518, 2014.

Low expression of myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3) is reportedly associated with gastric cancer and tumor progression. The purpose of this study was to examine the expression of MLL3 in tissue samples of patients with gastric cancer and to analyze the relationship between MLL3 protein expression and clinical records.

Association of DNA repair gene polymorphisms with response to chemotherapy and prognosis of gastric cancer

Z. H. Chen, Wang, L., and Luo, L. P., Association of DNA repair gene polymorphisms with response to chemotherapy and prognosis of gastric cancer, vol. 13, pp. 7484-7491, 2014.

We investigated the correlation between the response to chemotherapy in patients and excision repair cross-complimenta­ry group 1 gene (ERCC1) and xeroderma pigmentosum complemen­tation group F gene (XPF) polymorphisms and the effect of these polymorphisms on the clinical outcome of gastric cancer. Samples from a total of 255 patients with newly diagnosed and histopatho­logically confirmed primary gastric cancer were collected in our study.

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