Gastric cancer

Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study and a meta-analysis

W. G. Hu, Pan, R. J., Cai, W., Wang, Z. T., and Zhu, Z. G., Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study and a meta-analysis, vol. 14, pp. 14670-14679, 2015.

The association between the human 8-oxoguanine glycosylase 1 (hOGG1) gene Ser326Cys polymorphism (rs1052133) and gastric cancer has been widely evaluated, yet a definitive answer to whether this association exists is lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-analysis to further address this issue. This case-control study involved 448 patients clinically diagnosed with gastric cancer and 372 cancer-free control individuals from China.

Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells

F. J. Ji, Tian, X. F., Liu, X. W., Fu, L. B., Wu, Y. Y., Fang, X. D., and Jin, H. Y., Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells, vol. 14, pp. 15564-15571, 2015.

The aim of the present study was to determine the anti­proliferative and pro-apoptotic effects of dihydromyricetin (DHM) on the AGS human gastric cancer cells and their underlying mechanisms. The effects of DHM on AGS cells were evaluated by using 3-(4, 5-di­methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase, and Annexin V/propidium iodide (PI) double-staining assays. The underlying mechanisms were determined by using quanti­tative real-time polymerase chain reaction.

Subscribe to Gastric cancer