Gastric cancer

Association between the CDH1-472delA and -160C>A polymorphisms and diffuse and intestinal gastric cancer in a Mexican population

A. R. Bustos-Carpinteyro, Delgado-Figueroa, N., Santiago-Luna, E., Magaña-Torres, M. T., Sánchez-López, J. Y., Bustos-Carpinteyro, A. R., Delgado-Figueroa, N., Santiago-Luna, E., Magaña-Torres, M. T., and Sánchez-López, J. Y., “Association between the CDH1-472delA and -160C>A polymorphisms and diffuse and intestinal gastric cancer in a Mexican population”, vol. 15, p. -, 2016.

Gastric cancer (GC), the third leading cause of cancer-related deaths in Mexico and worldwide, can be classified into diffuse (DGC) or intestinal (IGC) types based on its histological characteristics. DGC is characterized by reduced expression of the cell adhesion protein E-cadherin, which is encoded by CDH1. The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in CDH1 induce a decrease in gene transcription; in fact, these mutated alleles have been associated with GC in some populations, with conflicting results.

Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer

J. Y. Gu, Tu, L., Gu, J. Y., and Tu, L., “Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer”, vol. 15, p. -, 2016.

Here, we performed a case-control study to investigate the role of miR-146a, miR-149, and miR-196a2 polymorphisms in the development of gastric cancer using a hospital-based case-control design. A total of 186 gastric cancer patients and 186 control subjects were enrolled from Ren Ji Hospital between January 2012 and October 2014. MicroRNAs miR-146a, miR-149, and miR-196a2 were genotyped by polymerase chain reaction coupled with restriction fragment length polymorphism.

IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

B. L. Xu, Li, Y. T., Dong, S. X., Qi, J., Feng, H. M., Zi, L., Yang, D. Y., Xu, B. L., Li, Y. T., Dong, S. X., Qi, J., Feng, H. M., Zi, L., and Yang, D. Y., “IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population”, vol. 15, p. -, 2016.

The purpose of this hospital-based case-control study was to assess whether the interleukin (IL)-17 rs2275913 genetic variation can influence susceptibility to gastric cancer. Samples from a total of 202 gastric cancer patients and 237 controls were collected from the Linyi People’s Hospital between March 2013 and March 2015. The IL-17 rs2275913 gene polymorphism was identified by polymerase chain reaction and restriction fragment length polymorphism.

miR-218 tissue expression level is associated with aggressive progression of gastric cancer

X. X. Wang, Ge, S. J., Wang, X. L., Jiang, L. X., Sheng, M. F., Ma, J. J., Wang, X. X., Ge, S. J., Wang, X. L., Jiang, L. X., Sheng, M. F., and Ma, J. J., “miR-218 tissue expression level is associated with aggressive progression of gastric cancer”, vol. 15, p. -, 2016.

The aim of the present study was to investigate the clinical significance of microRNA-218 (miR-218) in gastric cancer. We enrolled 112 patients having undergone surgery for gastric cancer between May 2008 and June 2014. Expression of miR-218 was determined by real-time quantitative reverse transcription-polymerase chain reaction. Survival curves were plotted using the Kaplan-Meier method and compared by the log-rank test. We found that miR-218 expression was significantly downregulated in gastric cancer tissues compared to adjacent normal tissues (P

Association between ERCC5 gene polymorphisms and gastric cancer risk

B. W. Guo, Yang, L., Zhao, R., Hao, S. Z., Guo, B. W., Yang, L., Zhao, R., and Hao, S. Z., “Association between ERCC5 gene polymorphisms and gastric cancer risk”, vol. 15, p. -, 2016.

We investigate the role of ERCC5 gene polymorphisms (rs17655 and rs751402) in the development of gastric cancer in a Chinese population. A total of 142 gastric cancer patients whose diagnoses were confirmed by pathology, and 274 control subjects were recruited from Tangshan Gongren Hospital between March 2013 and March 2015. Genotyping of ERCC5 rs17655 and rs751402 polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism.

Association between XPG gene polymorphisms and development of gastric cancer risk in a Chinese population

Y. B. Feng, Fan, D. Q., Yu, J., Bie, Y. K., Feng, Y. B., Fan, D. Q., Yu, J., and Bie, Y. K., “Association between XPG gene polymorphisms and development of gastric cancer risk in a Chinese population”, vol. 15, p. -, 2016.

We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene (rs2094258, rs751402 and rs17655) in the development of gastric cancer in a Chinese population. Between January 2012 and December 2014, samples from a total of 177 patients with gastric cancer and 237 control subjects were collected from the Ankang City Central Hospital.

Lack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population

J. J. Lu, Zhang, H. Q., Mai, P., Ma, X., Chen, X., Yang, Y. X., Zhang, L. P., Lu, J. J., Zhang, H. Q., Mai, P., Ma, X., Chen, X., Yang, Y. X., and Zhang, L. P., “Lack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population”, vol. 15, p. -, 2016.

We conducted a case-control study to assess the association between single nucleotide polymorphisms in the ERCC5 promoter (rs2094258 and rs751402) and development of gastric cancer in a Chinese population. This investigation included 184 patients with pathologically diagnosed gastric cancer and 206 healthy subjects recruited between October 2012 and December 2014. The genotyping of ERCC5 rs2094258 and rs751402 variants was performed by polymerase chain reaction coupled with restriction fragment length polymorphism.

A comprehensive review of microRNA-related polymorphisms in gastric cancer

B. W. Han, Li, Z. H., Liu, S. F., Han, H. B., Dong, S. J., Zou, H. J., Sun, R. F., Jia, J., Han, B. W., Li, Z. H., Liu, S. F., Han, H. B., Dong, S. J., Zou, H. J., Sun, R. F., and Jia, J., “A comprehensive review of microRNA-related polymorphisms in gastric cancer”, vol. 15, p. -, 2016.

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regulation of expression are strongly sequence dependent.

Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation of microRNA-451 and MMP-2 expression

Z. Peng, Zhang, Y., Peng, Z., Zhang, Y., Peng, Z., and Zhang, Y., “Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation of microRNA-451 and MMP-2 expression”, vol. 15, p. -, 2016.

Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell line were detected by an MTT assay and measurement of caspase-3 activity. The protein expression levels of matrix metalloproteinase-2 (MMP-2) were detected by western blotting.

Reduced expression of serum miR-204 predicts poor prognosis of gastric cancer

X. Chen, Liu, X. S., Liu, H. Y., Lu, Y. Y., Li, Y., Chen, X., Liu, X. S., Liu, H. Y., Lu, Y. Y., Li, Y., Chen, X., Liu, X. S., Liu, H. Y., Lu, Y. Y., and Li, Y., “Reduced expression of serum miR-204 predicts poor prognosis of gastric cancer”, vol. 15, p. -, 2016.

Deregulation of microRNAs (miRNAs) is implicated in the initiation and progression of gastric cancer (GC). Previous studies have demonstrated that miR-204 was downregulated in GC tissues. However, its expression profile in serum samples and its potential for clinical value remain unknown. Real-time PCR was performed to evaluate the expression level of serum miR-204 in patients with GC. The association between serum miR-204 expression level and the clinical outcome of GC was then investigated.

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