Gastric adenocarcinoma

Expression profiling of CEACAM6 associated with the tumorigenesis and progression in gastric adenocarcinoma

X. Deng, Liu, P., Zhao, Y., and Wang, Q., Expression profiling of CEACAM6 associated with the tumorigenesis and progression in gastric adenocarcinoma, vol. 13, pp. 7686-7697, 2014.

Carcinoembryonic antigen-related cellular adhesion molecule 6 (CEACAM6) is a member of the immunoglobulin superfamily and has been recently reported to affect the neoplastic, metastatic, and invasive ability of malignant cells by regulating intracellular signaling pathways during tumorigenesis and progression. We investigated the expression and amplification of CEACAM6 in relation to the clinicopathological and biological significance of gastric adenocarcinoma.

Preoperative chemotherapy with a trastuzumab-containing regimen for a patient with gastric cancer and hepatic metastases

Z. - Y. Li, Shan, F., Zhang, L. - H., Bu, Z. - D., Wu, A. - W., Wu, X. - J., Zong, X. - L., Li, S. - X., Ji, X., and Ji, J. - F., Preoperative chemotherapy with a trastuzumab-containing regimen for a patient with gastric cancer and hepatic metastases, vol. 13, pp. 10952-10957, 2014.

Gastric cancer is the fourth most common cancer worldwide and the leading cause of tumor-related death in China. Gastric cancer is a heterogeneous disease and therefore requires different treatments based on the subtype. We describe a patient who had gastric cancer with liver metastases. Biopsy and tumor analysis using the HercepTest revealed a human epidermal growth factor receptor 2 (HER2)-positive adenocarcinoma as confirmed by fluorescence in situ hybridization. The patient was treated with a regimen of trastuzumab, oxaliplatin, and S-1 (six cycles).

Telomerase activity could be used as a marker for neoplastic transformation in gastric adenocarcinoma: but it does not have a prognostic significance

G. Gümüþ-Akay, Ünal, A. E., Bayar, S., Karadayi, K., Elhan, A. H., Sunguroĝlu, A., Sunguroĝlu, A., and Tükün, A., Telomerase activity could be used as a marker for neoplastic transformation in gastric adenocarcinoma: but it does not have a prognostic significance, vol. 6, pp. 41-49, 2007.

Telomerase activity is responsible for telomere maintenance and is believed to be crucial in most immortal cells and cancer cells; however, its clinicopathological significance in gastric cancer remains to be clarified. The aim of the present study was to assess whether malignant progression of gastric adenocarcinoma correlates with telomerase activity. We also investigated the correlation between telomerase activity and histopathological findings. We examined telomerase activity in tumor specimens and adjacent normal tissues from 43 patients with gastric adenocarcinoma.

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