FSHB

Molecular cloning and sequence analysis of follicle-stimulating hormone beta polypeptide precursor cDNA from the bovine pituitary gland

L. S. Dai, Zhao, Y. M., Zhang, G. L., Zhao, R. F., Jiang, H., Ma, T. H., Gao, Y., Yuan, B., Xu, Y. L., Yu, W. Y., Zhao, Z. H., and Zhang, J. B., Molecular cloning and sequence analysis of follicle-stimulating hormone beta polypeptide precursor cDNA from the bovine pituitary gland, vol. 10, pp. 1504-1513, 2011.

Follicle-stimulating hormone (FSH) plays an essential role in mammalian spermatogenesis and follicular development. In a previous study, we demonstrated that some bulls carry numerous linked mutations in the FSH beta-subunit (FSHB) gene, and that these bulls have poor-quality semen, low fertility, and slightly lower serum FSH concentration compared to those without such mutations. Here, we identified the different FSHB mRNA transcripts in such individuals and analyzed the evolutionary pattern of the FSHB open reading frame (ORF) in different species.

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