A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood
“A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood”, vol. 10, pp. 3914-3923, 2011.
, Myostatin is a secreted negative regulator of muscle mass, and follistatin antagonizes the function of several members of the TGF-b family, including myostatin. Previously, myostatin expression was found to be closely associated with atrophy of the gastrocnemius muscle, showing a linear correlation, after sciatic nerve injury. In this study, we investigated the possibility of myostatin being an indicator of denervated muscle atrophy.