Follistatin

A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood

R. H. Wu, Wang, P., Yang, L., Li, Y., Liu, Y., and Liu, M., A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood, vol. 10, pp. 3914-3923, 2011.

Myostatin is a secreted negative regulator of muscle mass, and follistatin antagonizes the function of several members of the TGF-b family, including myostatin. Previously, myostatin expression was found to be closely associated with atrophy of the gastrocnemius muscle, showing a linear correlation, after sciatic nerve injury. In this study, we investigated the possibility of myostatin being an indicator of denervated muscle atrophy.

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