Follicular development

Expression of hypoxia-inducible factor-1α during ovarian follicular growth and development in Sprague-Dawley rats

Z. H. Zhang, Chen, L. Y., Wang, F., Wu, Y. Q., Su, J. Q., Huang, X. H., Cheng, Y., and Wang, Z. C., Expression of hypoxia-inducible factor-1α during ovarian follicular growth and development in Sprague-Dawley rats, vol. 14, pp. 5896-5909, 2015.

Hypoxia-inducible factor-1α (HIF-1α) has been identified as a transcription factor that is involved in diverse physiological and pathological processes in the ovary. In this study, we examined whether HIF-1α is expressed in a cell- and stage-specific manner during follicular growth and development in the mammalian ovaries. Using immunohistochemistry and Western blot analysis, HIF-1α expression was observed in granulosa cells specifically and was significantly increased during the follicular growth and development of postnatal rats.

Gene expression in swine granulosa cells and ovarian tissue during the estrous cycle

P. V. Silva, Guimarães, S. E. F., Guimarães, J. D., Neto, J. B., Lopes, P. S., Nascimento, C. Sdo, de Campos, C. F., Weller, M. M. C. A., Botelho, M. E., and Faria, V. R., Gene expression in swine granulosa cells and ovarian tissue during the estrous cycle, vol. 10, pp. 2258-2267, 2011.

The components of the insulin-like growth factor (IGF) system appear to be involved in regulation of ovarian follicular growth and atresia in the pig. We investigated the expression pattern of mRNAs for IGF1 (IGF1), its binding proteins (IGFBP1, IGFBP2, IGFBP3, and IGFBP5), and epidermal growth factor in swine follicle cells and ovarian tissue throughout the estrous cycle using the real-time quantitative PCR technique.

Subscribe to Follicular development