Follicular atresia

Changes in the expression of FoxO1 and death ligand genes during follicular atresia in porcine ovary

F. Lin, Fu, Y. H., Han, J., Shen, M., Du, C. W., Li, R., Ma, X. S., and Liu, H. L., Changes in the expression of FoxO1 and death ligand genes during follicular atresia in porcine ovary, vol. 13, pp. 6638-6645, 2014.

Follicular atresia, a key phenomenon in follicle development, eliminates most of the follicles in mammalian ovaries. To investigate the molecular mechanism of follicular atresia in porcine ovaries, we investigated the mRNA expression of three important cell death ligand-receptor systems and Fox O1 in follicles with a diameter of 3-5 mm. The phosphorylation and subcellular localization of Fox O1 during granulosa cell apoptosis was also determined. TRAIL and Fas L played an important role in follicular atresia at this stage.

Rescue from dominant follicle atresia by follicle-stimulating hormone in mice

X. L. Zhou, Teng, Y., Cao, R., Fu, H., Xiong, K., Sun, W. X., Zhu, C. C., Huang, X. J., Xiao, P., and Liu, H. L., Rescue from dominant follicle atresia by follicle-stimulating hormone in mice, vol. 12, pp. 2945-2952, 2013.

We investigated the effects of follicle-stimulating hormone (FSH) on atresia of the dominant follicle and changes in relevant apoptosis genes in granulosa cells of dominant follicles regulated by FSH in vivo. Four-week-old mice were administered FSH by intraperitoneal injection to induce follicular maturation. Granulosa cells of dominant follicles were collected at 48, 72, and 96 h after the first FSH injection. Phosphate-buffered saline was injected as a control.

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