FAS ligand (FASLG)

MicroRNA-21 promotes proliferation of rat hepatocyte BRL-3A by targeting FASLG

J. J. Li, Chan, W. H., Leung, W. Y., Wang, Y., and Xu, C. S., MicroRNA-21 promotes proliferation of rat hepatocyte BRL-3A by targeting FASLG, vol. 14, pp. 4150-4160, 2015.

Rat liver regeneration (RLR) induced by partial hepatectomy involves cell proliferation regulated by numerous factors, including microRNAs (miRNAs). miRNA high-throughput sequencing has been established and used to analyze miRNA expression profiles. This study showed that 39 miRNAs were related to RLR through the analysis of miRNA high-throughput sequencing. Their role toward rat normal hepatocyte line BRL-3A was studied by gain- and loss-of-function analyses, and one of them, microRNA-21 (miR-21), obviously upregulated and promoted BRL-3A cell proliferation.

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