FAS -670A>G promoter polymorphism is associated with soluble Fas levels in primary Sjögren’s syndrome
“FAS -670A>G promoter polymorphism is associated with soluble Fas levels in primary Sjögren’s syndrome”, vol. 13, pp. 4831-4838, 2014.
, Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands. Soluble Fas receptor (sFas) has been suggested as a Fas-mediated apoptosis blocker that could impair clonal deletion in infiltrated autoreactive cells. The FAS -670A>G promoter polymorphism has been studied in pSS. However, a relationship between FAS -670A>G promoter polymorphism and sFas levels in pSS had not been found. We examined this relationship in 77 Mexican pSS patients and 84 healthy subjects were included.