Evodiamine

Long-term effects of evodiamine on expressions of lipogenesis and lipolysis genes in mouse adipose and liver tissues

D. F. Jiang, Li, W. T., Yang, H. L., Zhang, Z. Z., Chen, D., and Sun, C., Long-term effects of evodiamine on expressions of lipogenesis and lipolysis genes in mouse adipose and liver tissues, vol. 13, pp. 1038-1046, 2014.

Evodiamine, the major alkaloid component isolated from the fruit of dried, unripened Evodia rutaecarpa Bentham, affects the plasma levels of cholecystokinin and various biological events such as gastric emptying and gastrointestinal transit; these effects of evodiamine were previously investigated in male rats. In this study, we aimed to investigate the effects of evodiamine on average daily weight gain, rectal temperature, and expressions of genes involved in lipid metabolism in liver and adipose tissues.

Differential expression of lipid metabolism genes in the liver and adipose tissue of mice treated with evodiamine

D. F. Jiang, Zhang, X. G., Yang, H. L., and Sun, C., Differential expression of lipid metabolism genes in the liver and adipose tissue of mice treated with evodiamine, vol. 12, pp. 1501-1510, 2013.

Evodiamine is the main active alkali of Wu Zhuyu, a widely distributed Chinese herb. It plays an important role in the regulation of body fat deposition. In this study, we aimed to investigate the effect of evodiamine administration on the expression of genes involved in lipid metabolism in the liver and adipose tissue. Fasted mice were subcutaneously injected with evodiamine (37°C, 20 mg/kg), and the core body temperature change and expression levels of lipid metabolism-related genes were evaluated at baseline, 0.5, 1, and 2 h.

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